Evaluation of the effectiveness of intrathecal morphine compared with intravenous morphine analgesia pump

Evaluation of the effectiveness of intrathecal morphine compared with intravenous morphine analgesia pump in thoracotomy patients

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20240407061439N3

Enrollment

Registered

2026-05-22

Start date

2026-06-22

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients undergoing thoracotomy with resection of part of the lung. Malignant neoplasm of bronchus and lung

Interventions

Intervention 1: Intervention group: Group A patients were treated with analgesia using intrathecal morphine at a dose of 10 micrograms per kilogram. Intervention 2: Intervention group: Group B patient

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Age above 18 years and below 70 years Willingness to undergo neuraxial anesthesia Undergoing lobectomy or segmental lung resection surgery No infection or sepsis No coagulation disorders

Exclusion criteria

Exclusion criteria: Emergency surgery Hemodynamic instability infection or sepsis Hypersensitivity to morphine addiction or alcohol abuse Pregnant or breastfeeding patients

Design outcomes

Primary

Measure	Time frame
Reducing acute pain after thoracotomy. Timepoint: Examination of VAS scores at0/2/4/6/8/12/18/24 hours after surgery in patients. Method of measurement: Questionnaire and observation by an observer.	—

Secondary

Measure	Time frame
Check for respiratory depression (RR<8 and SPO2<90%) and the presence of clinical signs of respiratory distress. Timepoint: Time periods 0/2/4/6/8/12/18/24 hours after surgery in patients. Method of measurement: Questionnaire and observation by an observer.;Pruritus as a side effect in patients undergoing thoracotomy using morphine. Timepoint: At 0/2/46/8/12/18/24 hours after the surgery. Method of measurement: Questionnaire and observation by an observer.;Investigation of nausea and vomiting as a side effect in patients undergoing thoracotomy using morphine. Timepoint: At 0/2/46/8/12/18/24 hours after the surgery. Method of measurement: Questionnaire and observation by an observer.;• Investigating overall patient satisfaction in patients undergoing thoracotomy using morphine. Timepoint: 24 hours after surgery. Method of measurement: Questionnaire and observation by an observer.	—

Measure

Time frame

Check for respiratory depression (RR<8 and SPO2<90%) and the presence of clinical signs of respiratory distress. Timepoint: Time periods 0/2/4/6/8/12/18/24 hours after surgery in patients. Method of measurement: Questionnaire and observation by an observer.;Pruritus as a side effect in patients undergoing thoracotomy using morphine. Timepoint: At 0/2/46/8/12/18/24 hours after the surgery. Method of measurement: Questionnaire and observation by an observer.;Investigation of nausea and vomiting as a side effect in patients undergoing thoracotomy using morphine. Timepoint: At 0/2/46/8/12/18/24 hours after the surgery. Method of measurement: Questionnaire and observation by an observer.;• Investigating overall patient satisfaction in patients undergoing thoracotomy using morphine. Timepoint: 24 hours after surgery. Method of measurement: Questionnaire and observation by an observer.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMoein Daneshmand

Shahid Beheshti University of Medical Sciences

moein.daneshmand@sbmu.ac.ir+98 21 2712 3888

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Jun 11, 2026