The effect of oral tacrolimus with rectal indomethacin to reduce pancreatitis

Efficacy of Oral Tacrolimus Combined With Rectal Indomethacin Compared to Rectal Indomethacin Alone in Reducing Pancreatitis After ERCP

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20240327061376N1

Enrollment

Registered

2024-06-10

Start date

2024-03-20

Completion date

Unknown

Last updated

2024-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pancreatitis after ERCP. Other acute pancreatitis

Interventions

Intervention 1: Intervention group: Intervention group: Patients who meet the conditions to enter the study before the procedure are given oral tacrolimus along with rectal indomethacin and will be mo

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Normal amylase and lipase levels before ARCP All patients who meet the criteria for performing RCPI Having informed consent Full consciousness • No contraindications for tacrolimus

Exclusion criteria

Exclusion criteria: Pregnancy or breastfeeding History of previous angina, myocardial infarction, cerebral ischemia during the previous three months • Chronic heart, liver and kidney failure Referral with manifestations of acute pancreatitis or chronic pancreatitis • Tacrolimus contraindications include: uncontrolled blood pressure, uncontrolled infections, hypomagnesemia, hypocalcemia, hyperkalemia, and any type of malignancy. • Heart rhythm disorders • Thrombosis and DVT

Design outcomes

Primary

Measure	Time frame
Development of pancreatitis following ercp. Timepoint: 24 hours after ERCP. Method of measurement: Control of serum amylase and lipase levels of patients after the procedure in approved laboratories.;Reduction of pancreatitis by giving oral tacrolimus with rectal indomethacin after ercp. Timepoint: 24 hours after ERCP. Method of measurement: Control of amylase and lipase levels in patients after ERCP.	—

Measure

Time frame

Development of pancreatitis following ercp. Timepoint: 24 hours after ERCP. Method of measurement: Control of serum amylase and lipase levels of patients after the procedure in approved laboratories.;Reduction of pancreatitis by giving oral tacrolimus with rectal indomethacin after ercp. Timepoint: 24 hours after ERCP. Method of measurement: Control of amylase and lipase levels in patients after ERCP.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMorteza Valai

Mashhad University of Medical Sciences

valayimorteza@gmail.com+98 51 3876 7903

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026