Studying the effect of royal jelly on the treatment of tinnitus

Evaluating the Efficacy of Royal Jelly Compared to Placebo in Improving Tinnitus in Affected Patients: Randomized controlled trial

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20240327061371N3

Enrollment

Registered

2025-05-26

Start date

2025-05-31

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Tinnitus. Tinnitus

Interventions

Intervention 1: Intervention group: Participants in this group will receive an oral syrup containing royal jelly once daily for 30 consecutive days. Each dose consists of 10 milliliters of syrup per d

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Tinnitus and confirmation of the condition based on clinical diagnosis by an otolaryngologist and based on audiometry results (audiometry including tinnitus frequency) No history of allergy to royal jelly. No history of mental disorders or use of stimulant medications Not having hearing loss or deafness or using hearing aids Avoid taking ototoxic medications.

Exclusion criteria

Exclusion criteria: Concomitant use of other treatment strategies Unwillingness to participate in the study Allergy to royal jelly Organic causes, if diagnosed, such as Meniere's disease and acoustic neuroma Unilateral Tinnitus

Design outcomes

Primary

Measure	Time frame
Tinnitus severity based on the total score of the “Tinnitus Handicap Inventory” questionnaire, which assesses the impact of tinnitus on patients’ daily life. Timepoint: Tinnitus severity score will be measured at baseline (before the intervention) and at weeks 1, 3, 6, and 12 after the start of royal jelly syrup consumption. Method of measurement: Tinnitus severity will be assessed using the validated Persian version of the “Tinnitus Handicap Inventory” questionnaire, consisting of 25 questions rated on a five-point Likert scale.	—

Measure

Time frame

Tinnitus severity based on the total score of the “Tinnitus Handicap Inventory” questionnaire, which assesses the impact of tinnitus on patients’ daily life. Timepoint: Tinnitus severity score will be measured at baseline (before the intervention) and at weeks 1, 3, 6, and 12 after the start of royal jelly syrup consumption. Method of measurement: Tinnitus severity will be assessed using the validated Persian version of the “Tinnitus Handicap Inventory” questionnaire, consisting of 25 questions rated on a five-point Likert scale.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactAfrooz Eshaghian

Esfahan University of Medical Sciences

afroozeshaghian@med.mui.ac.ir+98 31 3233 0092

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026