Skip to content

Effect of topical timolol on recurrent epistaxis

Effect of topical timolol on recurrent epistaxis: a clinical trial

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20240327061371N1
Enrollment
70
Registered
2025-03-02
Start date
2024-10-31
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

epistaxis. Epistaxis

Interventions

Intervention 1: Intervention group: half percent timolol nasal spray manufactured by Raha Pharmaceutical Company, one puff in each nostril twice a day for 4 weeks. Intervention 2: Control group: Norma

Sponsors

Esfahan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: History of recurrent epistaxis with at least 4 episodes in the last four weeks

Exclusion criteria

Exclusion criteria: Pregnancy Having bronchial asthma or chronic lung disease Suffering from diseases that cause coagulation problems, such as hemophilia Patients with low blood pressure Having pheochromocytoma or severe peripheral blood circulation disorders Receiving calcium antagonists History of nose surgery in the last month breastfeeding Having chronic lung disease Patients with heart failure Patients with bradycardia Patients with other cardiac contraindications for beta-blockers Patients with peripheral vascular circulation dysfunction Receiving amiodarone Receiving antiarrhythmics Receiving clonidine Receiving lidocaine Receiving beta blockers Receiving fluctafenine Receiving soltopride Hypersensitivity to timolol Use of anticoagulants

Design outcomes

Primary

MeasureTime frame
Epistaxis. Timepoint: Before the intervention and 2 weeks, 4 weeks, and 8 weeks after the intervention. Method of measurement: History taking.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAfrooz Eshaghian

Esfahan University of Medical Sciences

afroozeshaghian@med.mui.ac.ir+98 31 3233 0091

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026