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Effect of Empagliflozine on fatty liver

Evaluation of the effect of Empagliflozine on inflammatory, oxsidative stress and biochemistry markers in patients with non-alchoholic fatty liver disease in comparison with control group

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20240326061366N1
Enrollment
40
Registered
2024-05-18
Start date
2024-08-22
Completion date
Unknown
Last updated
2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Non alcoholic fatty liver. Fatty (change of) liver, not elsewhere classified

Interventions

Intervention 1: Intervention group: Empagliflozine receivers with dose of 10mg po daily for 8 weeks from Abidipharma company. Intervention 2: Control group: patients in this group receive diet program

Sponsors

Yasouj University of Medical Sciences
Lead Sponsor
Doosti motlagh laboratory
Collaborator

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Ages greater than 18 Fatty liver sonography findings ALT levels greater than 33 in non diabetic male and greater than 25 in non diabetic female Personal interest to participate Consumption of non or less than 20 grams of alcohol per day in female and non or less than 30 grams of alcohol per daY in male No history of malignancies,cardiovascular respiratory and renal complications, No history of weight loss or weight loss surgery No history of drug consumption and no history of metabolic and endocrine complications No history of liver enhancing drugs such as Vit E,Liver goal,Liver med ...

Exclusion criteria

Exclusion criteria: No interest in participating Pregnancy or breastfeeding in female No drug use compatibility Allergy to Empagliflozine Participating in other clinical studies

Design outcomes

Primary

MeasureTime frame
Alanine transaminase. Timepoint: Before the start of study and 8 weeks after intervention. Method of measurement: Calorimetry withhitachi autoanalyzer 7020.

Secondary

MeasureTime frame
C reactive protein. Timepoint: Before intervention and 8 weeks after the start of intervention. Method of measurement: Laser nephelometry.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAmirhossein Doostimotlagh

Yasouj University of Medical Sciences

amirhosseindoustimotlagh@gmail.com+98 74 3323 5153

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026