Myocardial infarction. ST elevation (STEMI) myocardial infarction of unspecified site
Conditions
Interventions
Intervention 1: Intervention group: Receive 1200 mg oral pentoxifylline (maximum daily dose of pentoxifylline
three 400 mg tablets, generic form) immediately before PCI treatment. Intervention 2: Control group: Standard treatment for STEMI is according to the American College of Heart Foundation (ACCF)/Americ
Sponsors
Bagheiat-allah University of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Diagnosis of STEMI, as chest pain lasting more than 30 minutes and less than 12 hours with ST-segment elevation at the J point on the ECG for more than 1 mm in at least two consecutive leads Precancerous coronary intervention successful sinus rhythm Informed consent to participate in the study
Exclusion criteria
Exclusion criteria: Recent history (within 3 months) of coronary artery bypass grafting Receive thrombolytic therapy Recent electrophysiological interventions of the heart Cardiogenic shock at the time of presentation History of kidney failure (Creatinine > 2.5 mg/dL) Allergy and contraindication to aspirin, clopidogrel or pentoxifylline Those who are pregnant or breastfeeding Dissatisfaction and those who want to stop the study at any time
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Troponion I. Timepoint: Upon entering the emergency room and then 8, 16 and 32 hours after revascularization treatment. Method of measurement: Blood test.;Interleukin 6. Timepoint: On arrival in the emergency room and 48 hours and 15 days after revascularization treatment. Method of measurement: Blood Test.;Hs-CRP. Timepoint: On arrival in the emergency room and 48 hours and 15 days after revascularization treatment. Method of measurement: Blood test.;CPK. Timepoint: On arrival to the emergency department as a baseline sample and every 8 hours to 48 hours after revascularization treatment. Method of measurement: Blood test. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAlireza Nasiri
Bagheiat-allah University of Medical Sciences
Outcome results
None listed