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Investigation of vitamin C and vitamin E co-treatment in improvement of clinical and paraclinical findings of lung contusion patients

Investigation of vitamin C and vitamin E co-treatment in improvement of clinical and paraclinical findings of lung contusion patients

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20240316061302N1
Enrollment
40
Registered
2024-09-24
Start date
2024-10-22
Completion date
Unknown
Last updated
2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lung contusion. Contusion of lung

Interventions

Intervention 1: Intervention group: Intravenous infusion of vitamin E (1000 IU in 50 ml of emulsion) and intravenous infusion of vitamin C (500 mg in 50 ml of normal saline) on two occasions with an i

Sponsors

Kerman University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients with lung contusion due to blunt trauma to the chest based on clinical findings (including respiratory distress, hypoxemia, tachypnea, decreased breath sounds, hypercarbia, subcutaneous emphysema) and radiological or CT scan findings (focal and non-segmental opacity in the lung parenchyma) Consent of the patient or the patient's guardian (if the patient is not sufficiently conscious) to participate in the study Hospitalized in Shahid Bahonar Hospital in 1402-1401 Age above 18 years

Exclusion criteria

Exclusion criteria: penetrating trauma Patients under intubation for more than 3 days Patients requiring major surgical intervention (including brain, abdominal or major orthopedic surgery such as hip or femur fracture) Patients with a history of COPD or asthma GCS less than 13 Having pulmonary edema, pneumonia or ARDS blood exchange Lack of consent of the patient or the patient's guardian to enter the study

Design outcomes

Primary

MeasureTime frame
Length of stay in ICU. Timepoint: From the time of admission to the hospital until discharge from the ICU. Method of measurement: Calendar.;Arterial Blood Gas Analysis. Timepoint: Before drug administration and 24 and 48 hours after drug administration. Method of measurement: ABG measuring laboratory device.;ESR. Timepoint: Before drug administration and 24 and 48 hours after drug administration. Method of measurement: ESR measuring laboratory device.;WBC. Timepoint: Before drug administration and 24 and 48 hours after drug administration. Method of measurement: CBC measuring laboratory device.;Final outcome (death, discharge). Timepoint: length of hospitalization. Method of measurement: Ducumantation.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFiroozeh Abolhasanizadeh

Kerman University of Medical Sciences

Firoozeh_228@yahoo.com+98 34 3223 5011

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026