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Evaluation of the efficacy of duloxetine and venlafaxine in chemotherapy-induced neuropathy in cancer patients,A double-blind clinical trial with placebo

Evaluation of the efficacy of duloxetine and venlafaxine in chemotherapy-induced neuropathy in cancer patients,A double-blind clinical trial with placebo

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20240314061286N1
Enrollment
141
Registered
2024-04-18
Start date
2024-03-21
Completion date
Unknown
Last updated
2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Drug-induced polyneuropathy. Drug-induced polyneuropathy

Interventions

Intervention 1: Intervention group: Cancer patients treated with chemotherapy will be treated with duloxetine. Group A patient are treated with 30 mg of duloxetine capsules in the first week and then

Sponsors

Gorgan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Age over 18 years and under 80 years Cancer patients based on the diagnosis of the physician and the pathology sample Willingness and consent to participate in the study Do not use drugs that affect serotonin levels Do not use painkillers and drugs effective on neuropathic pain routinely from two weeks before starting duloxetine or venlafaxine

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Comparison of the average BPI score in the group treated with duloxetine and venlafaxine and placebo. Timepoint: at the beginning of treatment, weeks 6 and 12. Method of measurement: brief pain inventory.;Comparison of mean SF36 score in the group treated with duloxetine and venlafaxine and placebo. Timepoint: at the beginning of treatment, weeks 6 and 12. Method of measurement: Item short form survey36.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactNajmeh shahini

Gorgan University of Medical Sciences

Najmeh.shahini@gmail.com+98 17 3243 0319

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026