Investigation of efficacy of postbiotic mouthwash on oral mucositis

Investigation of efficacy of postbiotic mouthwash on oral mucositis induced by chemotherapy and radiotherapy in head and neck cancers

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20240313061280N1

Enrollment

Registered

2024-04-18

Start date

2024-04-20

Completion date

Unknown

Last updated

2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Oral mucositis due to radiation. Oral mucositis (ulcerative) due to radiation

Interventions

Intervention 1: Intervention group: lysate synbiotic mouthwash containing two strains of Lactobacillus plantarum and Lactobacillus johnsoni - rinse the mouthwash three times a day and each time for th

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Head and neck cancers patients who underwent chemoradiation

Exclusion criteria

Exclusion criteria: if patients does not want to continue trails, after documenting the reason, they will exclude. if, for any reason, the mouthwash is not used in more than 20% of days.

Design outcomes

Primary

Measure	Time frame
Oral mucositis (any severity with RTOG grading). Timepoint: Before intervention, then weekly up to 7 weeks. Method of measurement: RTOG grading scale.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactNasrin Moazzen

Mashhad University of Medical Sciences

n.moazzen@gmail.com+98 51 3879 5031

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026