Comparing the effect of levofloxacin with metronidazole in the eradication of Helicobacter pylori

Comparing the effectiveness of the four-drug regimen containing levofloxacin with the effectiveness of the four-drug regimen containing metronidazole in the treatment of Helicobacter pylori eradication

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20240311061259N1

Enrollment

162

Registered

2024-10-10

Start date

2024-10-06

Completion date

Unknown

Last updated

2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Helicobacter pylori. Helicobacter pylori [H. pylori] as the cause of diseases classified elsewhere

Interventions

Intervention 1: Intervention group: Receiving quadruple therapy of omeprazole, bismuth, amoxicillin and levofloxacin. Intervention 2: Intervention group: receiving quadruple therapy of omeprazole, bis

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: positive helicobacter pylori

Exclusion criteria

Exclusion criteria: History of previous eradication therapy for Helicobacter pylori History of gastrectomy Stomach malignancy (including adenocarcinoma and lymphoma) Use of antibiotics (amoxicillin, clarithromycin, tinidazole) in the last four weeks

Design outcomes

Secondary

Measure	Time frame
Side effect of drugs. Timepoint: During the intervention and after the completion of the intervention. Method of measurement: History and clinical examination.	—

Primary

Measure	Time frame
Helicobacter pylori eradication. Timepoint: Before the intervention and 14 days after the intervention. Method of measurement: stool antigen test.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMahshid Malekian

Shahid Beheshti University of Medical Sciences

mahshidmalekian2023@gmail.com+98 21 2243 2525

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026