The effect of topical herbal oil based on lavender, Acorus calamus and Turmeric on Taxanes -induced peripheral neuropathy in cancer

The effect of topical herbal oil based on lavender, Acorus calamus and Turmeric on Taxanes -induced peripheral neuropathy in cancer patients

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20240306061184N1

Enrollment

Registered

2025-04-23

Start date

2024-07-22

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Taxanes-induced peripheral neuropathy. Drug-induced polyneuropathy

Interventions

Intervention 1: Intervention group: In the test group, the participants are asked to apply 1 cc of oil (vegetable) on the surface of the foot (from the ankle to the tip of the toes) and the surface of

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Patients with breast, gynecological and urology cancer in the age range of 18-80 years with complaints of peripheral neuropathy symptoms, according to the opinion of a neurologist; their neuropathy is due to chemotherapy with taxane drugs. Are undergoing chemotherapy or have a history of chemotherapy, provided that no more than two months have passed since the completion of their chemotherapy, regardless of the number of chemotherapy courses.

Exclusion criteria

Exclusion criteria: Having diabetes and other neuropathies such as Guillain-Barré, multiple sclerosis, and carpal tunnel syndrome Allergy to herbal medicines Stage 4 cancer patients Patients who perform radiotherapy at the same time as chemotherapy

Design outcomes

Primary

Measure	Time frame
Sensory and motor disorders and pain and symptoms of neuropathy in the lower and upper limbs. Timepoint: The beginning of the study (before the start of the intervention) and 28 days after the start of topical herbal oil consumption (the end of the intervention). Method of measurement: To quantitatively evaluate peripheral neuropathy before and after intervention(Questionnaire FACT/GOG-Ntx Version 4)Functional Assessment of Cancer Therapy for patients with neurotoxicity questionnaire - version 4 (FACT-GOG-NTX), Qualitative symptoms of peripheral neuropathy based on the scalePNQ (Patient Neurotoxicity Questionnaire), Pain before and after the intervention; Neuropathic Pain Scale (NPS).	—

Measure

Time frame

Sensory and motor disorders and pain and symptoms of neuropathy in the lower and upper limbs. Timepoint: The beginning of the study (before the start of the intervention) and 28 days after the start of topical herbal oil consumption (the end of the intervention). Method of measurement: To quantitatively evaluate peripheral neuropathy before and after intervention(Questionnaire FACT/GOG-Ntx Version 4)Functional Assessment of Cancer Therapy for patients with neurotoxicity questionnaire - version 4 (FACT-GOG-NTX), Qualitative symptoms of peripheral neuropathy based on the scalePNQ (Patient Neurotoxicity Questionnaire), Pain before and after the intervention; Neuropathic Pain Scale (NPS).

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Secondary

Measure	Time frame
Registration of possible complications. Timepoint: While studying. Method of measurement: Side effects registration form.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Yosofpoor

Mazandaran University of Medical Sciences

m.yousefpour@mazums.ac.ir+98 11 3324 4893

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026