Evaluating the effect of ethanol extract of propolis on palatal wound healing and complications after gingival graft surgery

Evaluating the effects of ethanolic extract of propolis mucoadhesives on palatal epithelial wound healing and post-operative complications after free gingival graft surgery

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20240305061182N1

Enrollment

Registered

2024-07-19

Start date

2024-07-21

Completion date

Unknown

Last updated

2024-07-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The wound of palate in patients who need gingival graft.

Interventions

Intervention 1: Intervention group: Mucoadhesive containing 10% ethanol extract of propolis that produced in the Department of Pharmacology of Babol University of Medical Sciences, which will be place

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: patients over 18 years old patients who need free gingival graft The existence of sufficient dimensions of the free gingival graft donor site in the palate (length :10-15 mm, width :5-8 mm, thickness:1-1.5 mm)

Exclusion criteria

Exclusion criteria: Systemic diseases and conditions affecting wound healing (such as uncontrolled diabetes, autoimmune diseases, history of alcoholism) Clinical attachment loss(greater than 3 mm) in the palatal site of premolars and maxillary first molars. Use of corticosteroids Use of antibiotics in the last month Smoking Allergy to amoxicillin-ibuprofen-chlorhexidine mouthwash Allergy to bee products Asthma

Design outcomes

Primary

Measure	Time frame
Response to pain in patients after surgery. Timepoint: on days 3-7-14-21-42. Method of measurement: VAS (VISUAL ANALOGUE SCALE).;Response of patients to thermal stimuli after surgery. Timepoint: On days 3-7-14-21. Method of measurement: VAS (VISUAL ANALOGUE SCALE).;Complete epithelialization. Timepoint: on days 3-7-14-21-42. Method of measurement: Landry healing index.;Evaluating the degree of color matching, contour and distortion. Timepoint: on days 3-7-14-21-42. Method of measurement: Modified Manchester Scar Proforma index.	—

Measure

Time frame

Response to pain in patients after surgery. Timepoint: on days 3-7-14-21-42. Method of measurement: VAS (VISUAL ANALOGUE SCALE).;Response of patients to thermal stimuli after surgery. Timepoint: On days 3-7-14-21. Method of measurement: VAS (VISUAL ANALOGUE SCALE).;Complete epithelialization. Timepoint: on days 3-7-14-21-42. Method of measurement: Landry healing index.;Evaluating the degree of color matching, contour and distortion. Timepoint: on days 3-7-14-21-42. Method of measurement: Modified Manchester Scar Proforma index.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactNiloufar Jenabian

Babol University of Medical Sciences

njenabian@hotmail.com+98 11 3219 9592

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026