Comparison of the effect of Dexamethasone and Hydrocortisone on hemodynamics

Comparison of two drugs, dexamethasone and hydrocortisone, on the hemodynamic responses of tonsillectomy patients in Bandarabass Payambar Azam Complex in 2024-2025.

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20240304061162N1

Enrollment

236

Registered

2024-03-18

Start date

2024-03-20

Completion date

Unknown

Last updated

2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Complications of tonsillectomy surgery. Unspecified complication of procedure, initial encounter

Interventions

Intervention 1: Intervention group: Patients in the dexamethasone group receive an intravenous dose of 0.5 mg/kg of dexamethasone. This drug is prescribed before induction of anesthesia. Induction of

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: All patients who refer to Bandar Abbas Shahid Mohammadi Hospital for tonsillectomy.

Exclusion criteria

Exclusion criteria: Patients who have allergies or contraindications to dexamethasone or hydrocortisone drugs. Patients taking medications that may interfere with medications or hemodynamic responses. Underlying diseases: conditions such as heart disease, hypertension, or any other condition that can affect hemodynamic responses.

Design outcomes

Primary

Measure	Time frame
Change in blood pressure. Timepoint: Blood pressure measurement before intubation, 1 minute, 3 minutes and 5 minutes after intubation and every 5 minutes after that. Method of measurement: Digital blood pressure gauge.;Changes in heart rate. Timepoint: Heart rate measurement before intubation, 1 minute, 3 minutes and 5 minutes after intubation and every 5 minutes after that. Method of measurement: Heart rate monitor.	—

Measure

Time frame

Change in blood pressure. Timepoint: Blood pressure measurement before intubation, 1 minute, 3 minutes and 5 minutes after intubation and every 5 minutes after that. Method of measurement: Digital blood pressure gauge.;Changes in heart rate. Timepoint: Heart rate measurement before intubation, 1 minute, 3 minutes and 5 minutes after intubation and every 5 minutes after that. Method of measurement: Heart rate monitor.

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Secondary

Measure	Time frame
Cough. Timepoint: As long as the patient is in the recovery room. Method of measurement: Observing the presence or absence of cough.;Chills. Timepoint: As long as the patient is in the recovery room. Method of measurement: Observing the presence or absence of chills.;Nausea. Timepoint: As long as the patient is in the recovery room. Method of measurement: Observing the presence or absence of nausea.;Vomit. Timepoint: As long as the patient is in the recovery room. Method of measurement: Observing the presence or absence of Vomit.;Laryngeal spasm. Timepoint: During tracheal tube removal. Method of measurement: Observing the presence or absence of Laryngeal spasm.	—

Measure

Time frame

Cough. Timepoint: As long as the patient is in the recovery room. Method of measurement: Observing the presence or absence of cough.;Chills. Timepoint: As long as the patient is in the recovery room. Method of measurement: Observing the presence or absence of chills.;Nausea. Timepoint: As long as the patient is in the recovery room. Method of measurement: Observing the presence or absence of nausea.;Vomit. Timepoint: As long as the patient is in the recovery room. Method of measurement: Observing the presence or absence of Vomit.;Laryngeal spasm. Timepoint: During tracheal tube removal. Method of measurement: Observing the presence or absence of Laryngeal spasm.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Matin Yadollahi

Bandare-abbas University of Medical Sciences

matin.yadollahi78@gmail.com+98 71 3641 9256

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026