Comparison of the effect of myo-inositol alone and in combination with standard treatment on fertility outcomes in women with polycystic ovary syndrome undergoing IVF treatment

Comparison effect of myoinositol supplement alone and with metformin and sitagliptin in infertile women with polycystic ovary syndrome treated with IVF

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20240303061157N2

Enrollment

125

Registered

2025-10-09

Start date

2025-10-23

Completion date

Unknown

Last updated

2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Polycystic ovary syndrome. Polycystic ovary syndrome

Interventions

Intervention 1: Control group: They will receive 500 mg of metformin daily. Intervention 2: First intervention group: They will receive 2 grams of myo-inositol daily. Intervention 3: Second interventi

Eligibility

Sex/Gender

Female

Age

20 Years to 35 Years

Inclusion criteria

Inclusion criteria: Infertile women with classic polycystic ovary syndrome

Exclusion criteria

Exclusion criteria: Patients with hypersensitivity to metformin Patients with hypersensitivity to dipeptidyl peptidase-4 inhibitors Male-related infertility Patients with congenital adrenal hyperplasia Patients with thyroid gland disorders Patients with Cushing's syndrome Patients with androgen-secreting neoplasia Patients with severe liver disease Patients with severe kidney disease Patients with gallstones

Design outcomes

Primary

Measure	Time frame
No. of Oocyte retrieved. Timepoint: Once, in day of puncture. Method of measurement: Oocyte retrieval will be performed by ultrasound-guided transvaginal aspiration using a single-lumen needle.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactForogh Forghani

Zahedan University of Medical Sciences

f.forghani@zaums.ac.ir+98 54 3337 2013

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026