Frozen embryo transfer in modified natural cycle. Evaluation and comparison of clinical pregnancy rate in two methods of endometrial preparation using hormone therapy method and modified natural cycle of in frozen embryo transfer cycle
Conditions
Interventions
Intervention group: Patients in the modified normal cycle (mNC-FET) group underwent transvaginal ultrasound on day 10 to 12 of the menstrual cycle to determine the size of the dominant follicle and th
Sponsors
Mazandaran University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: Age 20-40 years with monthly menstrual cycles of 21 to 35 days Normal BMI (18-30 kg/m2) At the time of embryo transfer, there should be at least one or two embryos with good-quality Patients with first or second transfer
Exclusion criteria
Exclusion criteria: Women who were diagnosed with uterine anatomic abnormalities, either inborn or acquired, hydrosalpinx, and endometriosis. The patients with ovulation disorders. Women who needed preimplantation genetic testing. Women who suffered from recurrent miscarriages and recurrent implantation failure. Women with medical conditions who were interdicted ART/pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical pregnancy so that the heartbeat of the fetus can be seen in ultrasound. Timepoint: 5 weeks after embryo transfer or 8th week of pregnancy. Method of measurement: By transvaginal ultrasound. | — |
Secondary
| Measure | Time frame |
|---|---|
| The rate of chemical pregnancy in which only the pregnancy test is positive (B-hCG> 50 IU/l), but no clinical pregnancy was confirmed on vaginal ultrasound in the 8th week. Timepoint: the 8th week of pregnancy. Method of measurement: Laboratory test and transvaginal ultrasound.;Miscarriage rate (loss of clinical pregnancy before the 12th gestational week). Timepoint: before the 12th gestational week. Method of measurement: Trans vaginal ultrasound.;Implantation rate (IR was defined as the number of gestational sacs determined by sonogram divided by the number of frozen embryos transferred ). Timepoint: 6th gestational week. Method of measurement: transvaginal ultrasound.;Ectopic pregnancy rate (EPR) (refers to the presence of a gestational sac outside the uterine cavity). Timepoint: 6 to 7th gestational week. Method of measurement: Laboratory test and transvaginal ultrasound.;Twin pregnancy rate (TPR). Timepoint: the 8th week of pregnancy. Method of measurement: transvaginal ultrasound.;Ongoing pregnancy (Ongoing pregnancy was defined as a continuation of pregnancy after the 12th week of gestation). Timepoint: after the 12th week of gestation. Method of measurement: Abdominal ultrasound.;Rates of positive hCG,( positive hCG was defined as B-hCG > 50 IU/l measured 14 days after transfer). Timepoint: 14 days after embryo transfer. Method of measurement: Laboratory test.;Cycle cancelation: in mnc If there were no dominant follicles (follicle diameter = 16 mm) until the 16th day, the cycle was canceled. In hrc, the cycle was canceled if the endometrial thickness was still insufficient after 18 days of estrogen administration. Timepoint: in mnc 16th day cycle and 18th day cycle in hrc. Method of measurement: transvaginal ultrasound.;Number of visit(Number of visits from the start of the cycle to embryo transfer). Timepoint: from the start of the cycle to embryo transfer. Method of measurement: According to the patient's file. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactFarnaz Safarlou
Mazandaran University of Medical Sciences
Outcome results
None listed