Investigating the effect of saffron capsules on irritable bowel syndrome

Effect of saffron capsules compared to placebo in the adjunctive treatment of patients with irritable bowel syndrome with predominant diarrhea and constipation referring to Imam Khomeini Hospital in 2024, a double-blind clinical trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20240223061091N1

Enrollment

Registered

2024-07-16

Start date

2024-08-20

Completion date

Unknown

Last updated

2024-07-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Irritable bowel syndrome. Irritable bowel syndrome

Interventions

Intervention 1: The intervention group should take one saffron capsule daily. It is recommended to consume the capsule before the main meal and not to take it with any other medication or supplement w

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: All patients with irritable bowel syndrome

Exclusion criteria

Exclusion criteria: Age less than 18 years Having a chronic gastrointestinal disease such as IBD

Design outcomes

Primary

Measure	Time frame
Determining the prevalence of depression in patients with irritable bowel syndrome. Timepoint: When visiting a gastroenterology or psychiatric clinic. Method of measurement: Hospital Depression Questionnaire.;Determining the prevalence of anxiety in patients with irritable bowel syndrome. Timepoint: When visiting a gastroenterology or psychiatric clinic. Method of measurement: Hospital anxiety scale questionnaire.;The effect of saffron consumption in reducing the symptoms of irritable bowel syndrome. Timepoint: Follow up of patients for 4 and 8 weeks after starting saffron medicine. Method of measurement: Irritable Bowel Syndrome (IBS) Questionnaire and Hospital Anxiety and Depression Scale (HADS).;The effect of saffron consumption on the severity of anxiety in patients. Timepoint: Follow up of patients for 4 and 8 weeks after starting saffron medicine. Method of measurement: Hospital anxiety scale questionnaire.;The effect of saffron consumption on the severity of patients' depression. Timepoint: Follow up of patients for 4 and 8 weeks after starting saffron medicine. Method of measurement: Hospital Depression Questionnaire.	—

Measure

Time frame

Determining the prevalence of depression in patients with irritable bowel syndrome. Timepoint: When visiting a gastroenterology or psychiatric clinic. Method of measurement: Hospital Depression Questionnaire.;Determining the prevalence of anxiety in patients with irritable bowel syndrome. Timepoint: When visiting a gastroenterology or psychiatric clinic. Method of measurement: Hospital anxiety scale questionnaire.;The effect of saffron consumption in reducing the symptoms of irritable bowel syndrome. Timepoint: Follow up of patients for 4 and 8 weeks after starting saffron medicine. Method of measurement: Irritable Bowel Syndrome (IBS) Questionnaire and Hospital Anxiety and Depression Scale (HADS).;The effect of saffron consumption on the severity of anxiety in patients. Timepoint: Follow up of patients for 4 and 8 weeks after starting saffron medicine. Method of measurement: Hospital anxiety scale questionnaire.;The effect of saffron consumption on the severity of patients' depression. Timepoint: Follow up of patients for 4 and 8 weeks after starting saffron medicine. Method of measurement: Hospital Depression Questionnaire.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactZahra Arabi

Tehran University of Medical Sciences

zari_arabi@yahoo.com+98 21 6119 0000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026