Investigating the Effect of Magnesium Supplementation on Outcomes Related to Anesthesia Quality in Pregnant Women Undergoing Emergency Caesarean Section

Investigating the Effect of Magnesium Sulfate as an Adjunct to Rocuronium on Intubation Quality and Hemodynamic Changes in Pregnant Women Undergoing Emergency Caesarean Section

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20240221061070N4

Enrollment

100

Registered

2025-03-02

Start date

2025-04-23

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The management of neuromuscular blockade in patients undergoing emergency cesarean section under general anesthesia, focusing on optimizing muscle relaxation and recovery using magnesium sulfate as an adjunct to rocuronium..

Interventions

Intervention 1: Intervention Group: In this group, patients will undergo general anesthesia using the following protocol: Propofol is administered at a dose of 2.5 mg/kg intravenously (IV) for inducti

Eligibility

Sex/Gender

Female

Age

18 Years to 45 Years

Inclusion criteria

Inclusion criteria: Patient undergoing cesarean section with general anesthesia

Exclusion criteria

Exclusion criteria: Malampaty III or IV History of difficult intubation History of face and neck radiation Emergency surgery due to mother or baby Taking previous magnesium sulfate History of face or neck trauma Patients recently used calcium channel blockers Patients recently used antibiotics, especially aminoglycosides Patient receiving labetalol History of allergy to rocuronium History of allergy or complications of receiving succinyl colin Neuromuscular diseases History of malignant hyperthermia Creatinine more than 1.5 or glomerular filtration less than 60

Design outcomes

Primary

Measure	Time frame
Intubating conditions. Timepoint: Immediately after intubation. Method of measurement: Intubation condition assessment checklist in accordance with the guidelines for Good Clinical Research Practice (GCRP) in Pharmacodynamic Studies of Neuromuscular Blocking Agents.	—

Secondary

Measure	Time frame
Blood pressure. Timepoint: Before and one minute after the induction of anesthesia, one minute and three minutes after intubation. Method of measurement: Blood pressure monitoring device.;Heart rate. Timepoint: Before and one minute after the induction of anesthesia, one minute and three minutes after intubation. Method of measurement: Vital signs monitoring device.;Saturation of peripheral oxygen (SPO2). Timepoint: Before and one minute after the induction of anesthesia, one minute and three minutes after intubation. Method of measurement: Vital signs monitoring device.	—

Measure

Time frame

Blood pressure. Timepoint: Before and one minute after the induction of anesthesia, one minute and three minutes after intubation. Method of measurement: Blood pressure monitoring device.;Heart rate. Timepoint: Before and one minute after the induction of anesthesia, one minute and three minutes after intubation. Method of measurement: Vital signs monitoring device.;Saturation of peripheral oxygen (SPO2). Timepoint: Before and one minute after the induction of anesthesia, one minute and three minutes after intubation. Method of measurement: Vital signs monitoring device.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMilad Masaeli

Esfahan University of Medical Sciences

drmilmas@gmail.com+98 81 8485 3541

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026