Preventive effect of dexamethasone and paracetamol on postoperative pain following cesarean section

Comparative study of the preventive effect of different doses of dexamethasone and paracetamol on postoperative pain in patients undergoing cesarean section

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20240221061070N11

Enrollment

200

Registered

2026-01-07

Start date

2025-11-22

Completion date

Unknown

Last updated

2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post-Cesarean Pain (Postoperative Pain after Cesarean Section). Other acute postprocedural pain

Interventions

Intervention 1: Intervention Group 1 (Intravenous dexamethasone 2 mg):In this group, aiming to evaluate the preventive effect of low-dose dexamethasone on postoperative pain intensity, after obtaining

Eligibility

Sex/Gender

Female

Age

18 Years to 45 Years

Inclusion criteria

Inclusion criteria: Women with American Society of Anesthesiologists (ASA) physical status class I Age range between 18 and 45 years Candidates for elective cesarean section under spinal anesthesia

Exclusion criteria

Exclusion criteria: Known cardiac, pulmonary, hepatic, or renal disease Psychiatric disorders, diabetes mellitus, or thyroid dysfunction Body temperature at operating room admission 37.5 °C History of alcohol or substance abuse Use of vasodilator medications Requirement of intraoperative blood transfusion

Design outcomes

Primary

Measure	Time frame
Postoperative pain intensity after cesarean section. Timepoint: Postoperative pain intensity using the Visual Analog Scale (VAS) will be assessed at baseline (before administration of the study intervention and prior to the start of surgery) and subsequently at 2, 4, 6, and 8 hours after surgery (following receipt of the intervention). Method of measurement: The primary variable (postoperative pain intensity) will be measured using the Visual Analogue Scale for pain assessment. This scale consists of a 10-centimeter horizontal line with “no pain” marked at one end (score 0) and “the worst pain imaginable” at the other end (score 10).At each predefined postoperative time point (0, 2, 4, 6, and 8 hours after the cesarean section), the patient will indicate the intensity of pain by marking a point on the line corresponding to their perceived pain level. The score is obtained by measuring the distance in centimeters from the “no pain” anchor to the patient’s mark.Before surgery, all participants will be instructed on how to use the scale to ensure a consistent and valid understanding of pain rating across subjects.	—

Measure

Time frame

Postoperative pain intensity after cesarean section. Timepoint: Postoperative pain intensity using the Visual Analog Scale (VAS) will be assessed at baseline (before administration of the study intervention and prior to the start of surgery) and subsequently at 2, 4, 6, and 8 hours after surgery (following receipt of the intervention). Method of measurement: The primary variable (postoperative pain intensity) will be measured using the Visual Analogue Scale for pain assessment. This scale consists of a 10-centimeter horizontal line with “no pain” marked at one end (score 0) and “the worst pain imaginable” at the other end (score 10).At each predefined postoperative time point (0, 2, 4, 6, and 8 hours after the cesarean section), the patient will indicate the intensity of pain by marking a point on the line corresponding to their perceived pain level. The score is obtained by measuring the distance in centimeters from the “no pain” anchor to the patient’s mark.Before surgery, all participants will be instructed on how to use the scale to ensure a consistent and valid understanding of pain rating across subjects.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMilad Masaeli

Esfahan University of Medical Sciences

drmilmas@gmail.com+98 31 3236 7001

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 7, 2026