Comparison of the effectiveness of calcifidiol and calcicalciferol on clinical outcomes of burn patients. Calcification and ossification of muscles associated with burns
Conditions
Interventions
Intervention 1: Intervention group: Patients in the first group received 0.25 micrograms of calcitriol daily (one pearl containing 0.25 micrograms of calcitriol, in the form of lactose
Galinus Aria Company, Iran) for two weeks. Intervention 2: Intervention group: The second group received cholecalciferol, Vitamin D3 1000 soft gel capsules (Dana Pharmaceutical Company, Iran), daily f
Sponsors
Yazd University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Burn patients 18 to 65 years old Superficial, deep second-degree burns, and third-degree burns based on criteria American burn associated Ability to swallow medicine Total body surface area : 20-50% Hospitalization for at least 2 weeks
Exclusion criteria
Exclusion criteria: Blood hydroxyvitamin D25 level greater than or equal to 30 ng/dl at admission Blood calcium level above the upper limit of normal in the hospital laboratory upon admission Kidney failure stage 4 and above intubated patients Gavaj patients
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome of this study was the patient's wound healing, which was assessed using a standardized tool called the Bates–Jensen Wound Assessment Tool, which is measured in three stages. Timepoint: It is measured in three stages: upon admission, at the end of the first week, and at the end of the second week of hospitalization. Method of measurement: The 15-question tool for assessing wound status and burn healing is scored on a Likert scale, with a score of 1 representing the best condition and a score of 5 representing the worst condition. Thirteen components are numerically scored, and the other two components are only descriptive. The total score range is 13-65. (Bates–Jensen Wound Assessment Tool Questionnaire). | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in the patient's serum vitamin D3 levels. Timepoint: It is measured twice, at the time of entry and after the intervention is completed. Method of measurement: Radio- Immuno-Assay method.;Investigating the role of interventions on liver enzymes. Timepoint: It is measured twice, at the time of entry and after the intervention is completed. Method of measurement: Radio- Immuno-Assay method.;Investigating the effects of interventions on patients' fasting blood sugar. Timepoint: It is measured twice, at the time of entry and after the intervention is completed. Method of measurement: Radio- Immuno-Assay method.;Residual scar score based on Vancouver score scale. Timepoint: Immediately after the intervention, one month later, and three months after the intervention. Method of measurement: The Vancouver scar scale (VSS) is one of the most validated clinical tools for qualitative assessment of burn scars, scoring them based on four main scar characteristics: pigmentation, vascularity, flexibility, and scar thickness. The total score ranges from 0 (normal) to 13 (severe). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactGolnaz Afzal
Yazd University of Medical Sciences
Outcome results
None listed