Investigating the effect of trans-oxamic acid intra-articular injection to reduce bleeding

Investigating the Intra-articular injection of tranexamic acid via a drain plus drain-clamping to reduce blood loss in cemented total knee arthroplasty

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20240217061034N2

Enrollment

Registered

2025-01-28

Start date

2025-02-18

Completion date

Unknown

Last updated

2025-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The effect of trans-oxamic acid intra-articular injection in reducing bleeding after cement knee joint replacement.

Interventions

Intervention 1: Intervention group: The drain will be clamped for 1 hour and 2 and 3 hours. Intervention 2: Control group: The control group will be patients who will have intra-articular injections a

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: Patients undergoing total knee replacement Patients under cemented unilateral primary total knee Informed consent of the patient

Exclusion criteria

Exclusion criteria: Known allergy to TXA Cementless TKA Bilateral TKA Posteriorly stabilized TKA Patients with a history of cerebral hemorrhage Patients with kidney problems Thromboembolism Other contraindications to its injection

Design outcomes

Primary

Measure	Time frame
Bleeding volume. Timepoint: 1, 2, 3 hours after clamping the drain. Method of measurement: The volume of bleeding inside the drain is measured using milliliters (ml). This value is accurately extracted from the volume of blood inside the drain.;Hemoglobin level. Timepoint: Before the operation and 24 hours after the operation. Method of measurement: Hemoglobin level with the help of blood sampling and testing.	—

Measure

Time frame

Bleeding volume. Timepoint: 1, 2, 3 hours after clamping the drain. Method of measurement: The volume of bleeding inside the drain is measured using milliliters (ml). This value is accurately extracted from the volume of blood inside the drain.;Hemoglobin level. Timepoint: Before the operation and 24 hours after the operation. Method of measurement: Hemoglobin level with the help of blood sampling and testing.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr.Mir Bahram Safari

Oroumia University of Medical Sciences

safari.mb@umsu.ac.ir+98 44 3346 9931

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026