Intra-articular injection of clindamycin in reducing postoperative infection rate of total knee arthroplasty

The effect of intra-articular injection of clindamycin in reducing postoperative infection rate of total knee arthroplasty: double-blind randomized clinical trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20240213061004N1

Enrollment

958

Registered

2024-05-24

Start date

2024-01-01

Completion date

Unknown

Last updated

2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Total knee arthroplasty. Other and unspecified infectious diseases

Interventions

Intervention 1: Intervention group: The combination of clindamycin with a dose of 600 mg with ketorolac, tranexamic acid and marcaine will intra-articular injection. Intervention 2: Control group: Ket

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with Degenerative Joint Disease Indications for total knee arthroplasty Informed consent

Exclusion criteria

Exclusion criteria: Lack of consent to participate in the study Suffering a disease other than degenerative joint disease Hypersensitivity to any of the drugs used in the study Dissatisfaction with performing total knee arthroplasty

Design outcomes

Primary

Measure	Time frame
Infection. Timepoint: 2 weeks, 1 month and 3 months. Method of measurement: Pain, heat, redness, swelling. If these symptoms are present, CRP and ESR are tested. If the results of the tests are abnormal, a smear and culture will be done for the patient from joint fluid aspiration, and if the results are positive, the case of joint infection will be known.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Mehdi Sarzaim

Tehran University of Medical Sciences

zabolianamirhossein@gmail.com+98 21 2260 0037

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026