Condition 1: Fatty Liver. Condition 2: Type 2 diabetes mellitus. Fatty (change of) liver, not elsewhere classified Type 2 diabetes mellitus
Conditions
Interventions
Intervention 1: Intervention group: The intervention in this group includes receiving a synbiotic supplement (produced by Zist Takhmir Company) containing one billion CFU in each capsule of strains of
Sponsors
Shiraz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Having fatty liver (grade 2 or 3) Having diabetes or prediabetes (fasting blood sugar above 100) Being overweight or obese (BMI greater than 25) Aged 18 or higher from both male and female genders Not taking insulin Not being pregnant or breastfeeding Not suffering from certain diseases, including metabolic, respiratory, and kidney diseases Not taking antibiotics or probiotic or synbiotic supplements in the 3 months before the study
Exclusion criteria
Exclusion criteria: Suffering from certain diseases during study, including respiratory and kidney diseases Taking multivitamins while studying Consumption of less than 80% of prescribed supplements Consumption of other probiotics during the study The need to take antibiotics Getting pregnant Requiring need for insulin
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Aspartate Aminotransferase. Timepoint: Before the start of the intervention and after the end of the intervention. Method of measurement: Standard enzymatic method. | — |
Secondary
| Measure | Time frame |
|---|---|
| Alanine aminotransferase. Timepoint: Before the start of the intervention and after the end of the intervention. Method of measurement: Standard enzymatic method.;Fasting blood sugar. Timepoint: Before the start of the intervention and after the end of the intervention. Method of measurement: Standard enzymatic method.;Triglyceride. Timepoint: Before the start of the intervention and after the end of the intervention. Method of measurement: Standard enzymatic method.;Total cholestrol. Timepoint: Before the start of the intervention and after the end of the intervention. Method of measurement: Standard enzymatic method.;Total antioxidant capacity. Timepoint: Before the start of the intervention and after the end of the intervention. Method of measurement: Standard enzymatic method.;Low-density lipoprotein. Timepoint: Before the start of the intervention and after the end of the intervention. Method of measurement: Standard enzymatic method.;High-density lipoprotein. Timepoint: Before the start of the intervention and after the end of the intervention. Method of measurement: Standard enzymatic method.;C-reactive protein. Timepoint: Before the start of the intervention and after the end of the intervention. Method of measurement: ELISA method.;Alkaline Phosphates. Timepoint: Before the start of the intervention and after the end of the intervention. Method of measurement: Standard enzymatic method.;Glycated hemoglobin. Timepoint: Before the start of the intervention and after the end of the intervention. Method of measurement: Standard enzymatic method.;Fasting insulin. Timepoint: Before the start of the intervention and after the end of the intervention. Method of measurement: ELISA method. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAryan Mohammad Yazdani
Shiraz University of Medical Sciences
Outcome results
None listed