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Comparison of the effect of surgical site skin preparation with povidone-iodine solution at two different temperatures on the antimicrobial effect and surgical wound infection

Comparison of the effect of surgical site skin preparation with povidone-iodine antiseptic at two different temperatures on the microbial load and surgical site infection in laparotomy patients

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20240212060966N1
Enrollment
126
Registered
2024-02-21
Start date
2024-04-13
Completion date
Unknown
Last updated
2024-03-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Surgical site infection.

Interventions

Intervention 1: Intervention group: surgical site Skin preparation will be done in two stages. At first, before starting the skin preparation process, a culture will be taken from the skin of the surg

Sponsors

Iran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 55 Years

Inclusion criteria

Inclusion criteria: Age 18 to 55 years Having at least a diploma degree No diabetes No history of laparotomy surgery Body mass index less than 35 Absence of immune system deficiency and no use of immunosuppressive drugs Absence of local infection near the surgical site or systemic infection Not being allergic to povidone-iodine antiseptic No history of malignancy and radiation therapy Absence of severe skin rash at the surgical site Not using broad-spectrum antibiotics within a month before going to the hospital having Elective surgery

Exclusion criteria

Exclusion criteria: Emergency laparotomy surgery Disruption in the surgical process that leads to the contamination of the instruments or the surgical field immune system deficiency and using immunosuppressive drugs having diabetes allergic to povidone-iodine antiseptic The presence of rashes and severe skin diseases at the surgical site using broad-spectrum antibiotics within a month before going to the hospital morbid obesity

Design outcomes

Primary

MeasureTime frame
Microbial load. Timepoint: microbial cultures will be taken in three stages before the surgical site skin preparation, after the initial stage of disinfection of the surgical site and after the secondary stage of disinfection of the surgical site with povidone-iodine 10%. Method of measurement: taking microbial culture and counting microbial colonies 24 hours after incubation.;Surgical site infection. Timepoint: Observation and examination of the surgical wound after 24 hours and 30 days after surgery. Method of measurement: Observing and examining the surgical wound and entering the symptoms in the surgical site infection checklist.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFardin Amiri

Iran University of Medical Sciences

amiri.fa@iums.ac.ir+98 21 8670 4600

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026