The effectiveness of Pomegranate flower on oral lichen lesions

Formulation and standardization of mucoadhesive form of Golnar (Punica granatum L.) and its effectiveness in erythematous and erosive lesions of oral lichen planus and its comparison with mucoadhesive form of triamcinolone: a randomized double-blind clinical trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20240212060964N1

Enrollment

Registered

2024-03-06

Start date

2024-05-21

Completion date

Unknown

Last updated

2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Erythematous and erosive lesions of oral lichen planus. Lichen planus

Interventions

Intervention 1: Intervention group: 20 patients who receive the mucoadhesive form containing Golnar 3 times a day. Intervention 2: Control group: 20 patients who receive triamcinolone mucoadhesive for

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Existence of clinical criteria and pathology of erythematous and erosive lesions of oral lichen planus

Exclusion criteria

Exclusion criteria: Patients with a history of chronic diseases such as hypertension, diabetes, etc. Active viral disease in the oral mucosa Patients with a history of allergy to herbal medicines-receiving local treatment in the last 2 weeks or systemic treatment in the last 4 weeks for lesions of oral lichen planus

Design outcomes

Primary

Measure	Time frame
- Determining the formulation of the adhesive mucus form containing Golnar- Determining the pH of the form of glue containing Golnar- Determining the release of the extract from the adhesive mucus ointment containing Golnar- Determining the amount of adhesiveness of the adhesive mucus form containing Golnar- Determining the rheological properties of the form of glue containing Golnar- Determining the microbial stability of the adhesive mucus form containing Golnar- Comparison of the average pain score of lichen planus between two groups of adhesive mucus form containing Golnar and triamcinolone adhesive form- Comparison of the average lichen plan score between the two groups of adhesive mucus form containing Golnar and triamcinolone adhesive mucus- Comparison of the frequency of lichen planus lesions between the two groups of adhesive mucus form containing golnar and triamcinolone adhesive mucus- Comparison of the average score of response to lichen planus treatment between two groups of adhesive mucus form containing Golnar and triamcinolone adhesive mucus- Comparison of the average duration of treatment of lichen planus between two groups of adhesive mucus form containing Golnar and triamcinolone adhesive mucus- Comparison of the average Lichen Plan pain score within each group before and after treatment- Comparison of the average score of Lichen Plan within each group before and after treatment- Comparison of the frequency of lichen planus lesions in each group before and after treatment- Comparison of the mean response score to lichen planus treatment within each group before and after treatment. Timepoint: The beginning of the study, 2, 4, 6 and 8 weeks after the start of the study. Method of measurement: - Pain ruler or Visual Analog Scale (VAS): A scaled page from 0 to 10 is given to the patients and according to the pain intensity of the lesions, a numerical score between 0 (in the absence of pain) and 10 (the most severe) is given.- The largest diameter of	—

Measure

Time frame

- Determining the formulation of the adhesive mucus form containing Golnar- Determining the pH of the form of glue containing Golnar- Determining the release of the extract from the adhesive mucus ointment containing Golnar- Determining the amount of adhesiveness of the adhesive mucus form containing Golnar- Determining the rheological properties of the form of glue containing Golnar- Determining the microbial stability of the adhesive mucus form containing Golnar- Comparison of the average pain score of lichen planus between two groups of adhesive mucus form containing Golnar and triamcinolone adhesive form- Comparison of the average lichen plan score between the two groups of adhesive mucus form containing Golnar and triamcinolone adhesive mucus- Comparison of the frequency of lichen planus lesions between the two groups of adhesive mucus form containing golnar and triamcinolone adhesive mucus- Comparison of the average score of response to lichen planus treatment between two groups of adhesive mucus form containing Golnar and triamcinolone adhesive mucus- Comparison of the average duration of treatment of lichen planus between two groups of adhesive mucus form containing Golnar and triamcinolone adhesive mucus- Comparison of the average Lichen Plan pain score within each group before and after treatment- Comparison of the average score of Lichen Plan within each group before and after treatment- Comparison of the frequency of lichen planus lesions in each group before and after treatment- Comparison of the mean response score to lichen planus treatment within each group before and after treatment. Timepoint: The beginning of the study, 2, 4, 6 and 8 weeks after the start of the study. Method of measurement: - Pain ruler or Visual Analog Scale (VAS): A scaled page from 0 to 10 is given to the patients and according to the pain intensity of the lesions, a numerical score between 0 (in the absence of pain) and 10 (the most severe) is given.- The largest diameter of

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSeyede Zahra Moravej

Tehran University of Medical Sciences

szm1376@gmail.com+98 21 8899 8378

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 7, 2026