Evaluation the comparison efficacy of topical DEMUlcent La' farrerr Cream with Diclofenac 1% gel on improvement of pain in patients with knee joint osteoarthritis

comparison of the effectiveness of a Topical Cream (DEMUlcent ™) Containing Arnica and Rosemary Extracts with Diclofenac 1% on improvement of pain in patients with knee joint osteoarthritis: A randomized Double-blind Control Trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20240210060954N1

Enrollment

284

Registered

2024-08-11

Start date

2024-08-22

Completion date

Unknown

Last updated

2024-08-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

osteoarthritis of knee joint. Osteoarthritis of knee

Interventions

Intervention 1: Intervention group: La' farrerr DEMUlcent Cream Containing Arnica, Rosemary, Chamomile Extracts and.../Used for 28days, Every 8 Hours at the pain location and Around. Intervention 2: C

Eligibility

Sex/Gender

All

Age

38 Years to 65 Years

Inclusion criteria

Inclusion criteria: patients with knee osteoarthritis (OA) with Kellegren-Lowrence garde 1-3 participants with knee joint osteoarthritis 38 to 65 years old

Exclusion criteria

Exclusion criteria: were pregnant or lactating had received NSAIDs, anti inflammatory treatment including oral and topical forms

Design outcomes

Primary

Measure	Time frame
Pain level. Timepoint: baseline, 14th, and the end of the study. Method of measurement: visual analogue scale (VAS).;Evaluate knee joint pain. Timepoint: baseline, 14th, and the end of the study. Method of measurement: Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) questionnaire.;Evaluate knee joint stiffness. Timepoint: baseline, 14th, and the end of the study. Method of measurement: WOMAC questionnaire.;Evaluate physical function. Timepoint: baseline, 14th, and the end of the study. Method of measurement: WOMAC questionnaire.	—

Measure

Time frame

Pain level. Timepoint: baseline, 14th, and the end of the study. Method of measurement: visual analogue scale (VAS).;Evaluate knee joint pain. Timepoint: baseline, 14th, and the end of the study. Method of measurement: Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) questionnaire.;Evaluate knee joint stiffness. Timepoint: baseline, 14th, and the end of the study. Method of measurement: WOMAC questionnaire.;Evaluate physical function. Timepoint: baseline, 14th, and the end of the study. Method of measurement: WOMAC questionnaire.

—

Secondary

Measure	Time frame
Evaluate Adverse event. Timepoint: During the study. Method of measurement: self-reporting.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Faraneh Farsad

Shahid Beheshti University of Medical Sciences

faraneh.farsad@sbmu.ac.ir+98 21 5541 9005

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026