systemic sclerosis. Systemic sclerosis [scleroderma]
Conditions
Interventions
Intervention 1: Intervention group: Taking Sildenafil 1% gel 15 grams (under the brand name Erecgel produced by Pishgam Daru Novin Pharmaceutical Company) every 8 hours. Intervention 2: Control group:
Sponsors
Shahre-kord University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Age over 18 and under 75 years Patients with systemic sclerosis diagnosed by ACR criteria or LeRoy ? Medsger Willingness to participate in the clinical trial Absence of MI, stroke or cardiac arrhythmia in recent 6 month Skin involvement limited to fingers, hands, face, forearms and feet
Exclusion criteria
Exclusion criteria: History of CKD (Creatinine clearance under ?? ml/minute) or cirrhosis (Child-Pugh class C) Overlap syndrome Hypersnsitivity to topical sildenafil
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of pain. Timepoint: Measurement of pain severity before the intervention and 2 and 6 weeks after the intervention. Method of measurement: Visual Analogue Scale (VAS) Questionnaire.;Quality of life. Timepoint: Measuring different aspects of quality of life before the intervention and 2 and 6 weeks after the intervention. Method of measurement: The World Health Organization Quality of Life Brief Version (WHOQOL-BREF).;Capiloroscopy of the nail bed of patients. Timepoint: before the intervention and 2 and 6 weeks after the intervention. Method of measurement: nailfold capiloroscope. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAlireza Rostamian
Shahre-kord University of Medical Sciences
Outcome results
None listed