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The effect of L-carnitine in non-alcoholic fatty liver disease

Efficacy of L-carnitine in decrease of liver enzymes and liver fat content in patients with non-alcoholic fatty liver disease

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20240129060837N1
Enrollment
102
Registered
2024-03-15
Start date
2024-03-24
Completion date
Unknown
Last updated
2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nonalcoholic fatty liver disease. Fatty (change of) liver, not elsewhere classified

Interventions

Intervention 1: Intervention group: Taking L-carnitine supplement at a dose of one gram every 12 hours for 3 months. Intervention 2: Control group: Taking placebo at a dose of one gram every 12 hours

Sponsors

Ahvaz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
15 Years to No maximum

Inclusion criteria

Inclusion criteria: AST, ALT levels above the normal range Sonographic findings consistent with fatty liver No history of viral hepatitis or conditions such as hemochromatosis, Wilson’s disease, autoimmune hepatitis, alpha-1 antitrypsin deficiency or chronic liver disease

Exclusion criteria

Exclusion criteria: Significant alcohol consumption (more than 10 grams per day for women and more than 20 grams per day for men) Pregnant or breastfeeding women

Design outcomes

Primary

MeasureTime frame
Decreased level of liver enzymes. Timepoint: Measurement of liver enzymes at the beginning of the study (before the start of the intervention) and 3 months after L-carnitine supplementation. Method of measurement: Check the level of liver enzymes in the serum by the laboratory.;Reducing the amount of liver fat. Timepoint: Measurement of liver enzymes at the beginning of the study (before the start of the intervention) and 3 months after L-carnitine supplementation. Method of measurement: Tansabdominal ultrasound.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAhmad Nezhadisalami

Ahvaz University of Medical Sciences

nejadisalami_a@ajums.ac.ir+98 61 3292 3985

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026