Condition 1: First Carpometacarpal Joint Osteoarthritis. Condition 2: First Carpometacarpal Joint Osteoarthritis. Unilateral primary osteoarthritis of first carpometacarpal joint Bilateral primary osteoarthritis of first carpometacarpal joints
Conditions
Interventions
Intervention 1: Intervention group: 25 patients with osteoarthritis of the first carpometacarpal joint who will be treated with intra-articular injection of collagen. Intervention 2: Control group: 25
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
40 Years to 70 Years
Inclusion criteria
Inclusion criteria: Patients with first carpometacarpal osteoarthritis based on radiographic criteria grade 2 and 3 and have moderate to severe pain (VAS>=5) in the first carpometacarpal joint for at least 3 months, which is resistant to drug treatment.
Exclusion criteria
Exclusion criteria: The patient's willingness to withdraw from the study at any stage of the design The presence of any acute or chronic infection of the joint or around the joint Pregnancy Any intra-articular injection of the first carpometacarpal joint was performed during the last three months. History of oral and systemic corticosteroid use in the last two weeks Use of NSAIDs within 2 weeks prior to injection Existence of inflammatory joint diseases such as rheumatoid arthritis, spondyloarthropathies, connective tissue diseases, gout, Paget's, septic arthritis History of neurological syndromes caused by entrapment of the peripheral nerves of the hands, such as carpal tunnel syndrome History of surgery in the hand Recent history of severe trauma to the hand Having a severe underlying disease such as uncontrolled diabetes Autoimmune and platelet disorders, treatment with anticoagulant and antiplatelet drugs within 10 days before injection Daily use of opioid and non-opioid analgesics Taking topical painkillers Hemarthrosis Erythema or psoriatic lesions at the injection site
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain in base of thumb. Timepoint: At the beginning of the study (before the start of the intervention) and one month and three months after the intervention. Method of measurement: Visual analogue scale (VAS).;Patient 's function. Timepoint: At the beginning of the study (before the start of the intervention) and one month and three months after the intervention. Method of measurement: FIHOA questionnaire scores.;The strength of the thumb. Timepoint: At the beginning of the study (before the start of the intervention) and one month and three months after the intervention. Method of measurement: Dynamometer.;The need for painkillers. Timepoint: At the beginning of the study (before the start of the intervention) and one month and three months after the intervention. Method of measurement: questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMohammad Faghihi Kashani
Shahid Beheshti University of Medical Sciences
Outcome results
None listed