Investigating the effect of aerobic exercise with and without blood occlusion in type 2 diabetes

Investigation of TCF7L2 gene expression following aerobic exercise with and without blood occlusion in white blood cells of type 2 diabetes patients

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20240125060808N1

Enrollment

100

Registered

2025-03-02

Start date

2023-04-19

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 diabetes. Type 2 diabetes mellitus

Interventions

Intervention 1: Intervention group: low to moderate intensity treadmill running aerobic exercises with blood vessel occlusion using the Anhuma company device for 3 sessions a week for 16 weeks. Interv

Eligibility

Sex/Gender

Male

Age

40 Years to 60 Years

Inclusion criteria

Inclusion criteria: History of type 2 diabetes for more than one year Not consuming insulin Age 40 to 60 years

Exclusion criteria

Exclusion criteria: Having a heart problem Not participating regularly in training session Smoking Not following health protocols

Design outcomes

Primary

Measure	Time frame
In the study "Investigation of TCF7L2 gene expression following aerobic exercise with and without blood vessel occlusion in white blood cells of type 2 diabetes patients" the primary outcome is "tcf7l2 gene (Transcription Factor 7-like 2) with the relative measure of fold unit". Timepoint: In the study "Investigation of TCF7L2 gene expression following aerobic exercise with and without blood vessel occlusion in white blood cells of type 2 diabetes patients", the time points of tcf7l2 measurement in all groups including the control group, the aerobic exercise group with blood flow obstruction and the aerobic exercise group without blood flow obstruction before the pre-test and 48 hours after the last exercise session at the end of the study. Method of measurement: In the study "Investigation of TCF7L2 gene expression following aerobic exercise with and without blood vessel blockage in white blood cells of type 2 diabetes patients", the method of measuring the variable " real-time polymerase chain reaction.	—

Measure

Time frame

In the study "Investigation of TCF7L2 gene expression following aerobic exercise with and without blood vessel occlusion in white blood cells of type 2 diabetes patients" the primary outcome is "tcf7l2 gene (Transcription Factor 7-like 2) with the relative measure of fold unit". Timepoint: In the study "Investigation of TCF7L2 gene expression following aerobic exercise with and without blood vessel occlusion in white blood cells of type 2 diabetes patients", the time points of tcf7l2 measurement in all groups including the control group, the aerobic exercise group with blood flow obstruction and the aerobic exercise group without blood flow obstruction before the pre-test and 48 hours after the last exercise session at the end of the study. Method of measurement: In the study "Investigation of TCF7L2 gene expression following aerobic exercise with and without blood vessel blockage in white blood cells of type 2 diabetes patients", the method of measuring the variable " real-time polymerase chain reaction.

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Secondary

Measure	Time frame
In the study "Investigation of TCF7L2 gene expression following aerobic exercise with and without blood vessel blockage in white blood cells of type 2 diabetes patients" secondary outcome of fasting blood sugar in mg/dL units. Timepoint: In the study "Examination of TCF7L2 gene expression following aerobic exercise with and without blood vessel occlusion in white blood cells of type 2 diabetes patients" the time points of fasting blood sugar measurement in all groups including the control group, the aerobic exercise group with blood flow obstruction and the aerobic exercise group without blood flow obstruction before the pre-test and 48 hours after the last exercise session at the end of the study. Method of measurement: In the study "Investigation of TCF7L2 gene expression following aerobic exercise with and without blood vessel occlusion in white blood cells of type 2 diabetes patients" how to measure fasting blood sugar using Delta kit and biochemistry autoanalyzer of Biotecnica brand BT3500.;In the study "Investigation of TCF7L2 gene expression following aerobic exercise with and without blood vessel occlusion in white blood cells of type 2 diabetes patients" is the secondary outcome of blood urea nitrogen with units of mg/dL. Timepoint: In the study "Investigation of TCF7L2 gene expression following aerobic exercise with and without blood vessel occlusion in white blood cells of type 2 diabetes patients", the time points of blood urea nitrogen measurement in all groups including the control group, the aerobic exercise group with blood flow obstruction and the aerobic exercise group without blood flow obstruction before the pre-test and 48 hours after the last exercise session at the end of the study. Method of measurement: In the study "Investigation of TCF7L2 gene expression following aerobic exercise with and without blood vessel occlusion in the white blood cells of type 2 diabetes patients," how to measure blood urea nitrogen using the Delta Kit and the Bio	—

Measure

Time frame

In the study "Investigation of TCF7L2 gene expression following aerobic exercise with and without blood vessel blockage in white blood cells of type 2 diabetes patients" secondary outcome of fasting blood sugar in mg/dL units. Timepoint: In the study "Examination of TCF7L2 gene expression following aerobic exercise with and without blood vessel occlusion in white blood cells of type 2 diabetes patients" the time points of fasting blood sugar measurement in all groups including the control group, the aerobic exercise group with blood flow obstruction and the aerobic exercise group without blood flow obstruction before the pre-test and 48 hours after the last exercise session at the end of the study. Method of measurement: In the study "Investigation of TCF7L2 gene expression following aerobic exercise with and without blood vessel occlusion in white blood cells of type 2 diabetes patients" how to measure fasting blood sugar using Delta kit and biochemistry autoanalyzer of Biotecnica brand BT3500.;In the study "Investigation of TCF7L2 gene expression following aerobic exercise with and without blood vessel occlusion in white blood cells of type 2 diabetes patients" is the secondary outcome of blood urea nitrogen with units of mg/dL. Timepoint: In the study "Investigation of TCF7L2 gene expression following aerobic exercise with and without blood vessel occlusion in white blood cells of type 2 diabetes patients", the time points of blood urea nitrogen measurement in all groups including the control group, the aerobic exercise group with blood flow obstruction and the aerobic exercise group without blood flow obstruction before the pre-test and 48 hours after the last exercise session at the end of the study. Method of measurement: In the study "Investigation of TCF7L2 gene expression following aerobic exercise with and without blood vessel occlusion in the white blood cells of type 2 diabetes patients," how to measure blood urea nitrogen using the Delta Kit and the Bio

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMina Rigi

University of Sistan and Baluchestan

mina.rigi.usb@gmail.com+98 54 3323 0725

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026