Type 2 diabetes. Type 2 diabetes mellitus
Conditions
Interventions
Intervention 1: Intervention group: Overweight patients with type 2 diabetes receiving selenium supplementation. The dose of zinc received will be 200 µg orally once a day. Supplementation will be don
Sponsors
Mazandaran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Age over 18 to 70 years old Definite diagnosis of type 2 diabetes mellitus based on clinical symptoms and laboratory findings. Overweight or obesity (BMI above 25) Obtaining written informed consent from patients
Exclusion criteria
Exclusion criteria: Selenium supplement use for at least three months before the start of the study History of other diseases related to oxidative stress and inflammation such as cardiovascular diseases, autoimmune diseases, IBD, asthma, cancer, kidney and liver diseases, infectious diseases Smoking and tobacco and alcohol use
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum insulin. Timepoint: Before the intervention, after the end of the intervention period. Method of measurement: Commercial ELISA kit.;Serum total antioxidant capacity. Timepoint: Before the intervention, after the end of the intervention period. Method of measurement: FRAP method.;Serum MDA. Timepoint: Before the intervention, after the end of the intervention period. Method of measurement: TBARS method.;Serum selenium. Timepoint: Before the intervention, after the end of the intervention period. Method of measurement: Atomic Absorption method.;Serum lipid profile. Timepoint: Before the intervention, after the end of the intervention period. Method of measurement: Commercial spectrophotometry kit.;Serum TNF-a. Timepoint: Before the intervention, after the end of the intervention period. Method of measurement: Commercial ELISA kit.;Serum CRP. Timepoint: Before the intervention, after the end of the intervention period. Method of measurement: Commercial kit.;Serum fasting glucose. Timepoint: Before the intervention, after the end of the intervention period. Method of measurement: Commercial kit.;HbA1C levels. Timepoint: Before the intervention, after the end of the intervention period. Method of measurement: Commercial kit.;Body Mass Index. Timepoint: Before the intervention, after the end of the intervention period. Method of measurement: Scales, meter.;Waist circumference. Timepoint: Before the intervention, after the end of the intervention period. Method of measurement: Meter. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMostafa Vaghari-Tabari
Mazandaran University of Medical Sciences
Outcome results
None listed