Metabolic syndrome. Metabolic syndrome
Conditions
Interventions
Intervention 1: Intervention group: Patients with metabolic syndrome receiving zinc supplementation. The dose of zinc received will be 30 mg orally once a day. Supplementation will be done for 12 week
Sponsors
Islamic Azad University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Age over 18 to 70 years old Definite diagnosis of metabolic syndrome based on clinical symptoms and laboratory findings. Overweight or obesity (BMI above 25) Obtaining written informed consent from patients
Exclusion criteria
Exclusion criteria: Taking zinc supplements at least three months before starting the study The need to take blood sugar and lipid lowering drugs according to the doctor's opinion History of other diseases related to oxidative stress and inflammation such as cardiovascular diseases, autoimmune diseases, types of diabetes, IBD, asthma, cancer, kidney and liver diseases, Infectious diseases Smoking and alcohol consumption
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum insulin. Timepoint: Before the intervention, after the end of the intervention period. Method of measurement: Commercial ELISA kit.;Serum MDA. Timepoint: Before the intervention, after the end of the intervention period. Method of measurement: TBARS method.;Serum zinc. Timepoint: Before the intervention, after the end of the intervention period. Method of measurement: Commercial spectrophotometry kit.;Serum total antioxidant capacity. Timepoint: Before the intervention, after the end of the intervention period. Method of measurement: FRAP method.;Serum lipid profile. Timepoint: Before the intervention, after the end of the intervention period. Method of measurement: Commercial spectrophotometry kit.;Serum CRP. Timepoint: Before the intervention, after the end of the intervention period. Method of measurement: Commercial kit.;Serum TNF-a. Timepoint: Before the intervention, after the end of the intervention period. Method of measurement: Commercial ELISA kit.;HbA1C levels. Timepoint: Before the intervention, after the end of the intervention period. Method of measurement: Commercial kit.;Serum fasting glucose. Timepoint: Before the intervention, after the end of the intervention period. Method of measurement: Commercial kit.;Body Mass Index. Timepoint: Before the intervention, after the end of the intervention period. Method of measurement: Scales, meter.;Waist circumference. Timepoint: Before the intervention, after the end of the intervention period. Method of measurement: Meter. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMostafa Vaghari-Tabari
Mazandaran University of Medical Sciences
Outcome results
None listed