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The effect of postbiotic mouthwash on oral ulcerative lichen planus lesions

The effect of mouthwash containing postbiotics on ulcerative lichen planus lesions of the oral mucosa: a double-blind randomized clinical trial study

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20240122060773N1
Enrollment
50
Registered
2024-07-19
Start date
2024-06-21
Completion date
Unknown
Last updated
2024-07-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

oral lichen planus. Lichen planus

Interventions

Intervention 1: Control group: routine treatment including combined mouthwash (ampoule of betamethasone or dexamethasone and MGS aluminum syrup and diphenhydramine compound syrup) 10 ampoules of betam

Sponsors

Tabriz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Patients suffering from ulcerative or erosive oral lichen planus based on the diagnosis of an oral disease expert in the clinical view and its confirmation by an oral pathologist from the biopsied tissue. Patients with pain higher than 2 on the visual analog scale during the initial clinical examination Age range from 18 to 60 years at the time of signing the informed consent At least one erosive mucosal tissue larger than 1 cm Consent to participate in the study

Exclusion criteria

Exclusion criteria: Patients with gastrointestinal ulcers Patients with uncontrollable and severe medical conditions Patients with dementia, mental disorders or alcohol addiction Pregnancy and breastfeeding Patients who have a history of taking immunosuppressive drugs in the last 4 weeks. Patients with dysplastic lesions

Design outcomes

Primary

MeasureTime frame
Intensity of pain. Timepoint: One week, two weeks and four weeks. Method of measurement: Visual Analogue Scale.;The size of oral ulcers. Timepoint: One week, two weeks and four weeks. Method of measurement: periodontal probe.;Recurrence rate. Timepoint: One week, two weeks and four weeks. Method of measurement: Therapist observation and patient report - periodontal probe and visual analog scale test.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSaba Jabbari Beyrami

Tabriz University of Medical Sciences

jabaris@tbzmed.ac.ir+98 41 3335 5965

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026