Hypertension. Essential (primary) hypertension
Conditions
Interventions
Intervention 1: Intervention Group: Patients are provided with a sodium salt substitute containing 70% sodium and 30% potassium chloride. They are instructed that using potassium salt is equivalent to
Sponsors
Karaj University of Medical Sciences
Eligibility
Sex/Gender
All
Age
40 Years to 65 Years
Inclusion criteria
Inclusion criteria: Patients aged 40 to 65 with confirmed HTN (having measured SBP>= 135mmHg). Patients with blood pressure who are undergoing treatment with blood pressure / anti-hypertensive medication Patients who primarily consume home-cooked meals Participants with written informed consent from both themselves and all their households
Exclusion criteria
Exclusion criteria: Patients using potassium-sparing diuretics, taking potassium supplements, or with any known acute or chronic kidney disease (CKD) are excluded from the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The mean of systolic blood pressure. Timepoint: The measurement is done at the beginning of the study (before the start of the intervention) and at the end of the study (6 months after the intervention) after consuming salt instead of sodium. Method of measurement: Mercury sphygmomanometer.;The mean of diastolic blood pressure. Timepoint: The measurement is done at the beginning of the study (before the start of the intervention) and at the end of the study (6 months after the intervention) after consuming salt instead of sodium. Method of measurement: Mercury sphygmomanometer.;The mean of blood pressure. Timepoint: The measurement is done at the beginning of the study (before the start of the intervention) and at the end of the study (6 months after the intervention) after consuming salt instead of sodium. Method of measurement: Mercury sphygmomanometer. | — |
Secondary
| Measure | Time frame |
|---|---|
| Urinary sodium to potassium ratio. Timepoint: The measurement is done at the beginning of the study (before the start of the intervention) and at the end of the study (3 & 6 months after the intervention) after consuming salt instead of sodium. Method of measurement: The result of dividing the sodium and potassium ratio of urine.;Serum creatinine. Timepoint: The measurement is done at the beginning of the study (before the start of the intervention) and at the end of the study (3 & 6 months after the intervention) after consuming salt instead of sodium. Method of measurement: Blood test.;Attitude of using regular salt or salt substitute. Timepoint: The measurement is done at the beginning of the study (before the start of the intervention) and at the end of the study (3 & 6 months after the intervention) after consuming salt instead of sodium. Method of measurement: Questionnaire.;Number/percent of individuals who develope hyperkalemia and hypokalemia. Timepoint: The measurement is done at the beginning of the study (before the start of the intervention) and at the end of the study (3 & 6 months after the intervention) after consuming salt instead of sodium. Method of measurement: Biochemical test.;Occurrence of CVD events such as TIA, cardiovascular accidents, occurrence/reoccurrence of strokes and reoccurrence of hypertensive crisis. Timepoint: The measurement is done at the beginning of the study (before the start of the intervention) and at the end of the study (3& 6 months after the intervention) after consuming salt instead of sodium. Method of measurement: Questionnaire.;Acceptability, usage, tolerance and taste of the blended salt and attitudes. Timepoint: The measurement is done at the beginning of the study (before the start of the intervention) and at the end of the study (3&6 months after the intervention) after consuming salt instead of sodium. Method of measurement: Questionnaire.;The mean of 24-hour sodium excretion. Timepoint: The measurement is done | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Mostafa Qorbani
Karaj University of Medical Sciences
Outcome results
None listed