Condition 1: Obesity. Condition 2: Autism. Overweight and obesity Autistic disorder
Conditions
Interventions
Intervention 1: Receiving Liraglutide (manufactured by Sinagene company under the brand name Melitide) as a subcutaneous injection at the rate of 3 mg per day for sixteen weeks (with 0.6 mg per day an
Sponsors
Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Age
12 Years to 18 Years
Inclusion criteria
Inclusion criteria: Having Autism with the confirmation of a specialist doctor using diagnostic indicators Being obese (be above the 95th percentile of BMI for age and sex) Have been lost less than 5 kg in the last three months Age 12 - 18 years Completion of consent form by patients parents
Exclusion criteria
Exclusion criteria: Liver or kidney failure Type 1 diabetes A history of suicide attempts or the existence of suicidal thoughts in a person or relatives Having thyroid cancer, C-cell thyroid tumors, MEN tumors or a family history of these tumors
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in BMI. Timepoint: At the beginning of the study, at the end of the fourth week, at the end of the tenth week, and at the end of the sixteenth week. Method of measurement: Height is measured using a standard inelastic meter and weight is measured using a standard fixed scale, then BMI is calculated using the formula.;Changes in BMI Z scores. Timepoint: At the beginning of the study, at the end of the fourth week, at the end of the tenth week, and at the end of the sixteenth week. Method of measurement: Height is measured using a standard inelastic meter and weight is measured using a standard fixed scale, then BMI is calculated using the; Then Z score is calculated. | — |
Secondary
| Measure | Time frame |
|---|---|
| FBS. Timepoint: The beginning and end of the study. Method of measurement: Using standard measurement kits.;Anthropometric data. Timepoint: The beginning and end of the study. Method of measurement: Anthropometry is done with the help of an Bioimpedance analysis (BIA) made by Tanita company.;HOMA-IR. Timepoint: The beginning and end of the study. Method of measurement: Using standard measurement kits.;Blood Triglyceride (TG) level. Timepoint: The beginning and end of the study. Method of measurement: Using standard measurement kits.;LDL. Timepoint: The beginning and end of the study. Method of measurement: Using standard measurement kits.;HDL. Timepoint: The beginning and end of the study. Method of measurement: Using standard measurement kits.;HbA1C. Timepoint: The beginning and end of the study. Method of measurement: Using standard measurement kits.;Hip circumference. Timepoint: The beginning and end of the study. Method of measurement: Using a non-stretchable standard meter, the largest hip circumference is measured.;Waist circumference. Timepoint: The beginning and end of the study. Method of measurement: The smallest waist circumference is measured using a non-elastic standard meter.;Circumference around the neck. Timepoint: The beginning and end of the study. Method of measurement: With the help of a non-stretchable standard meter, the neck circumference is measured in a standing position under the ridge of the throat. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMorteza Ghasemi
Mashhad University of Medical Sciences
Outcome results
None listed