Condition 1: Sepsis due to Acinetobacter. Condition 2: Pneumonia caused by Acinetobacter. Sepsis due to Acinetobacter baumannii Pneumonia due to Acinetobacter baumannii
Conditions
Interventions
Intervention 1: Intervention group A: Colistin: 9 million units of loading dose and then 4.5 million units every 12 hours along with adjust according to the patients GFR + meropenem: 2 grams (as an in
Sponsors
Gonabad University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Consent of the patient (in case of unconsciousness, his/her companion) to conduct the study ICU admission Probable or definite infection with ventilator-associated pneumonia or hospital-acquired pneumonia or urosepsis or blood infection of any origin Age 18 years or above Report of Acinetobacter in the culture from the site of infection Acinetobacter resistance to carbapenem
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical success after 14 days from the start of treatment. Timepoint: 14 days after the start of treatment. Method of measurement: The success of the treatment is defined by the presence of all the following criteria: • Alive patient • Stable hemodynamics (systolic blood pressure above 90 mmHg without the need for vasopressors) • Improvement or stability of the SOFA score (in patients whose initial SOFA score is equal to or greater than 3 be: an improvement of at least 30% of the score. In patients whose initial SOFA score is less than 3: reduction or stability of the score)• In patients with bacteremia: no growth of isolates on the 14th day. | — |
Secondary
| Measure | Time frame |
|---|---|
| All-cause mortality after 14 days. Timepoint: 14 days after the start of treatment. Method of measurement: Checking whether the patient is dead or alive on the 14th day.;All-cause mortality after 28 days. Timepoint: 28 days after the start of treatment. Method of measurement: Checking whether the patient is dead or alive on the 28th day (If the patient is discharged, his/her status will be checked by phone call).;Microbiological failure. Timepoint: 7 days after the start of treatment. Method of measurement: Isolation of the same bacteria as the initial isolate in the culture performed after 7 days from the start of treatment.;Duration of fever. Timepoint: Daily. Method of measurement: It is measured daily using an axillary thermometer.;Length of stay in ICU. Timepoint: Daily. Method of measurement: Calculation the length of time the patient is in the ICU (for non-deceased patients).;Length of stay in hospital. Timepoint: Daily. Method of measurement: Calculation of the number of days the patient is in the hospital (for non-deceased patients).;Adverse events. Timepoint: Daily. Method of measurement: Clinical evaluation. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMostafa Mansouri
Gonabad University of Medical Sciences
Outcome results
None listed