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Investigating the effect of valsartan sacubitril on left ventricular function

Evaluation of the effect of sacubitril valsartan on lv remodeling In patients with ischemic heart failure by 2D volumetry assessment

Status
Recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20240117060713N1
Enrollment
92
Registered
2024-01-27
Start date
2024-02-03
Completion date
Unknown
Last updated
2024-03-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ischemic Heart Disease. Other acute ischemic heart diseases

Interventions

Intervention 1: Intervention group: Valsartan (Arena company) treatment once a day for 6 months. Intervention 2: Intervention group: Treatment with sacubitril valsartan (Arena company) once a day for

Sponsors

Ahvaz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Consent to participate in the study Heart failure patients with LVEF less than 40 Coronary Artery Disease History of angioplasty Coronary artery bypass surgery

Exclusion criteria

Exclusion criteria: Insulin-dependent diabetes mellitus respiratory diseases Chronic kidney diseases Uncontrolled blood pressure

Design outcomes

Primary

MeasureTime frame
Left Ventricular Ejection Fraction. Timepoint: Before and after 6 months of intervention. Method of measurement: Echocardiography.;Left ventricular end-diastolic volume. Timepoint: Before and after 6 months of intervention. Method of measurement: Echocardiography.;Left Ventricular End-Systolic Volume. Timepoint: Before and after 6 months of intervention. Method of measurement: Echocardiography.

Secondary

MeasureTime frame
Duration of hospitalization. Timepoint: After 6 months of intervention. Method of measurement: Examination of patient records.;Mortality. Timepoint: After 6 months of intervention. Method of measurement: Examination of patient records.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFarzaneh Ahamdi

Ahvaz University of Medical Sciences

ahmadi-far@ajums.ac.ir+98 61 3311 0000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026