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The effect of two methods of using dexamethasone in reducing pain after root canal treatment

Investigating the effect of dexamethasone as the final rinse inside the root canal compared to infiltration injection after the end of treatment in reducing pain after root canal treatment in patients with irreversible pulpitis.

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20240109060657N1
Enrollment
96
Registered
2024-02-12
Start date
2024-02-14
Completion date
Unknown
Last updated
2024-03-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Irreversible pulpitis. Pulpitis

Interventions

Intervention 1: Intervention group 1: dexamethasone infiltration injection
After the end of the root treatment, a carpool (2 ml) of dexamethasone containing 8 mg of dexamethasone phosphate (as disodium salt) from Darou pakhsh company is infiltrated on the buccal side of the
After the preparation of the root canal and before filling the canal, the canal is washed with dexamethasone from Darou Pakhsh Company, and then the canal is dried and obturated. Intervention 3: Contr
The patient does not receive any intervention with dexamethasone during root canal treatment.

Sponsors

Boushehr University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Male and female patients Age over 18 years old Vital pulp with a diagnosis of symptomatic or asymptomatic pulpitis None of systemic diabetes and cardiovascular diseases and allergic problems Willingness to cooperate One-session root canal treatment The possibility of achieving patency in all canals in preoperative radiography Absence of periodontal problems

Exclusion criteria

Exclusion criteria: The complexity of the treatment and the possibility of prolonging the treatment time for more than 2 hours, which can be estimated from the patient's radiograph before starting the treatment. History of gastric ulcer or gastrointestinal bleeding History of allergy to NSAIDs or corticosteroids Risk of renal failure or renal damage

Design outcomes

Primary

MeasureTime frame
Average pain intensity. Timepoint: in the times before intervention, 3 hours after treatment, 6 hours, 12 hours, 24 hours after treatment. Method of measurement: NPRS ( Numeric Pain Rating Scale).

Countries

Iran (Islamic Republic of)

Contacts

Public Contactmina seyed habashi

Boushehr University of Medical Sciences

mina.s.habashi.64@gmail.com+98 77 3332 2081

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026