The effect of different doses of letrozole (2.5 mg for 10 days and 5 mg for 5 days) on ovulation induction in women with polycystic ovary syndrome

Investigating the effect of different doses of letrozole (2.5 mg for 10 days and 5 mg for 5 days) on the induction of ovulation in women with polycystic ovary syndrome

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20240109060656N4

Enrollment

112

Registered

2025-07-02

Start date

2025-07-23

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Polycystic ovary syndrome. Polycystic ovarian syndrome

Interventions

Intervention 1: Intervention group: The intervention group will be prescribed 2.5 mg of letrozole tablets daily for 10 days from the second day of the menstrual cycle or cessation of bleeding. Interve

Eligibility

Sex/Gender

Female

Age

18 Years to 44 Years

Inclusion criteria

Inclusion criteria: Women of childbearing age who have not become pregnant for more than 1 year without contraception Women diagnosed with polycystic ovary syndrome Women who have regular sex with the intention of conceiving

Exclusion criteria

Exclusion criteria: Women with BMI > 30 Women who concurrently received other pharmacological agents for ovulation induction, such as metformin, CC, and gonadotropins during ovulation induction Patients with tubal factor infertility Patients with infertility due to abnormalities in the male partner's semen

Design outcomes

Primary

Measure	Time frame
Ovulation induction. Timepoint: Days 21-23 of the menstrual cycle. Method of measurement: The size of the largest follicle during transvaginal ultrasound is determined by taking the average of the two internal diameters of the follicle measured in two perpendicular planes. HCG injection of 5000 IU is given to women with a follicular size =18 mm, and timely intercourse is recommended every other day from the day of HCG administration. Patients are advised to have serum progesterone measured on days 21-23 of the cycle. Typically, serum progesterone concentrations on days 21-23 of 3 are indicative of normal ovulation.	—

Measure

Time frame

Ovulation induction. Timepoint: Days 21-23 of the menstrual cycle. Method of measurement: The size of the largest follicle during transvaginal ultrasound is determined by taking the average of the two internal diameters of the follicle measured in two perpendicular planes. HCG injection of 5000 IU is given to women with a follicular size =18 mm, and timely intercourse is recommended every other day from the day of HCG administration. Patients are advised to have serum progesterone measured on days 21-23 of the cycle. Typically, serum progesterone concentrations on days 21-23 of 3 are indicative of normal ovulation.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactRosita Sadat Mohammadi

Shiraz University of Medical Sciences

rozita.mohammadi70@gmail.com009871332305410

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026