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Effect of meloxicam and naproxen in reducing pain and trismus after mandibular third molar surgery.

Comparison of the effects of meloxicam and naproxen in reducing pain and trismus after mandibular third molar surgery in patients requiring mandibular third molar surgery.

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20240109060656N3
Enrollment
80
Registered
2025-06-17
Start date
2025-07-06
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Impacted mandibular third molar. Impacted teeth

Interventions

Intervention 1: Intervention group: After surgery, meloxicam will be given at a dose of 7.5 mg every 12 hours for three days along with ibuprofen 400 mg every 6 hours for 3 days. Intervention 2: Contr

Sponsors

Shiraz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
17 Years to 35 Years

Inclusion criteria

Inclusion criteria: Age between 17 and 35 years old Need for surgery for impacted mesiangular mandibular third molar

Exclusion criteria

Exclusion criteria: Having taken painkillers or other medications within 24 hours before surgery Having a history of addiction to narcotics or painkillers Patients who are pregnant or breastfeeding Patients with known hypersensitivity to the analgesics used in the study

Design outcomes

Primary

MeasureTime frame
Pain. Timepoint: Days 1, 3, and 7 after surgery. Method of measurement: Postoperative pain is assessed using a 10-point visual analog scale (VAS), ranging from 0 for "no pain" to 10 for "worst possible pain.".;Trismus. Timepoint: Days 1, 3, and 7 after surgery. Method of measurement: Trismus is also measured by measuring the inter-incisal distance using a caliper and the results are reported with an accuracy of 0.01 mm.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactEhsan Aliabadi

Shiraz University of Medical Sciences

aliabadie@sums.ac.ir+98 71 3626 3193

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026