Skip to content

Effect of resistance training on Klotho and arterial stiffness in chronic kidney disease

Effect of 12 weeks of resistance training on Klotho-mediated arterial stiffness in subjects with chronic kidney disease

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20240107060639N1
Enrollment
32
Registered
2024-03-16
Start date
2023-04-03
Completion date
Unknown
Last updated
2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic kidney patients (CKD). Chronic kidney disease (CKD)

Interventions

Intervention 1: Intervention group: The exercise group will perform resistance exercises three days a week, resistance exercises in the present study will start 3 days a week with an intensity of 60%

Sponsors

Shahrood University of Technology
Lead Sponsor

Eligibility

Sex/Gender
All
Age
30 Years to 60 Years

Inclusion criteria

Inclusion criteria: In stage 3 to 5 of ckd disease, it means that their blood creatinine is higher than 1.5. Body mass index should be less than 40 Systolic blood pressure should be less than 18 and diastole less than 10 Have the ability to perform movement

Exclusion criteria

Exclusion criteria: Use of immunosuppressive drugs Smoking and tobacco use Having hypothyroidism and hyperthyroidism History of heart attack and stroke Congenital kidney disease Have regular physical activities

Design outcomes

Primary

MeasureTime frame
Central arterial stiffness with Cardio-ankle vascular index (CAVI). Timepoint: Before the start of the intervention (12 weeks of training) and 48 hours after the last training session. Method of measurement: Arterial stiffness was measured by oscillometric method using VaSera VS-2000 (Fukuda Denshi, Tokyo, Japan).;Peripheral arterial stiffness with ankle-brachial index (ABI). Timepoint: Before the start of the intervention (12 weeks of training) and 48 hours after the last training session. Method of measurement: ankle-brachial index was measured by oscillometric method using VaSera VS-2000 (Fukuda Denshi, Tokyo, Japan).;Blood plasma klotho levels. Timepoint: Before the start of the intervention (12 weeks of training) and 48 hours after the last training session. Method of measurement: By ELISA method with biochemical kits.

Secondary

MeasureTime frame
Maximum muscle strength (upper body and lower body). Timepoint: Before the start of the intervention (12 weeks of training) and 48 hours after the last training session. Method of measurement: Using the maximum repetition method.;Product of calcium and phosphorus. Timepoint: Before the start of the intervention (12 weeks of training) and 48 hours after the last training session. Method of measurement: By ELISA method with biochemical kits.;Vitamin D levels. Timepoint: Before the start of the intervention (12 weeks of training) and 48 hours after the last training session. Method of measurement: By ELISA method with biochemical kits.;Serum creatinine. Timepoint: Before the start of the intervention (12 weeks of training) and 48 hours after the last training session. Method of measurement: By ELISA method with biochemical kits.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAdel donyaei

Shahrood University of Technology

Adelldonyai@yahoo.com+98 23 3239 5900

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026