the effect of Citicoline on the retina in Non-Arteritic Anterior Ischemic Optic Neuropathy

The study of Optical coherence tomography and Optical coherence tomography angiography of the patients with Non-Arteritic Anterior Ischemic Optic Neuropathy before and after receiving Citicoline

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20240107060637N1

Enrollment

Registered

2024-01-28

Start date

2024-01-10

Completion date

Unknown

Last updated

2024-03-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Non-Arteritic Anterior Ischemic Optic Neuropathy.

Interventions

Intervention group: In this group, Citicoline ampule with a dose of 500 mg is injected intramuscularly once a week for 3 weeks..

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: The patient is in the first week of the attack Age: Older than 18 years

Exclusion criteria

Exclusion criteria: Consumption of Citicoline in the last three months as well as antioxidants and multivitamins and having a special diet Receiving previous treatment Congenital and acquired retinal diseases Presence of ocular pathology such as glaucoma, retinal disease and uveitis Taking corticosteroid drugs Taking Levodopa

Design outcomes

Primary

Measure	Time frame
The amount of damage in the thickness of the ganglion cell layer and optic nerve fiber layer is reduced in OCT images of the patient before and after receiving citicoline.2. Vascular density in OCTA should not be reduced. Timepoint: Patients will undergo paraclinical examinations during the first week of AION attack and one month after the start of treatment. Method of measurement: Optical coherence tomography and Optical coherence tomography angiography.	—

Measure

Time frame

The amount of damage in the thickness of the ganglion cell layer and optic nerve fiber layer is reduced in OCT images of the patient before and after receiving citicoline.2. Vascular density in OCTA should not be reduced. Timepoint: Patients will undergo paraclinical examinations during the first week of AION attack and one month after the start of treatment. Method of measurement: Optical coherence tomography and Optical coherence tomography angiography.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad reza Khalili

Shiraz University of Medical Sciences

khalilimr57@gmail.com+98 71 3230 2830

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026