Investigating and comparing the effectiveness of manual and mechanical ventilation on blood gases in patients under mechanical ventilation

Comparison of the impact of manual versus mechanical ventilation on arterial blood gases, end-tidal carbon dioxide and arterial oxygen saturation of patients under mechanical ventilation during cardiopulmonary resuscitation

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20240106060630N1

Enrollment

Registered

2024-04-07

Start date

2024-05-09

Completion date

Unknown

Last updated

2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cardiopulmonary arrest in patients with neuropathy diseases. Cardiac arrest, cause unspecified

Interventions

Intervention 1: Intervention group: The intervention group will receive ventilation during cardiopulmonary resuscitation through RESMED mechanical ventilation device. Ventilation with volume controlle

the initial arterial blood sample will be collected 2 minutes immediately after the start of CPR and 1 minute after achieving ROSC. Intervention 2: Control group: Control group: The control group will

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Age > 18 Definitive cardiopulmonary arrest diagnosis (no response, no carotid pulse, no breath) Patients with neuropathy diseases Patients with cv-line

Exclusion criteria

Exclusion criteria: Traumatic cardiac arrest Irreversible death Suspected COVID-19 Suspected pneumothorax Pregnant ROSC was achieved before intervention The patient's withdrawal from the research plan at the doctor's discretion Patients admitted to the hospital under cardiopulmonary resuscitation. Patients from whom initial arterial blood gas samples cannot be taken 2 minutes immediately after starting CPR.

Design outcomes

Primary

Measure	Time frame
End-tidal carbon dioxide. Timepoint: During cardiopulmonary resuscitation every 2 minutes. Method of measurement: A Sidestream portable capnography device from Comdek company, model MD-660P, made in Taiwan and manufactured in 2005.;Arterial oxygen saturation. Timepoint: During cardiopulmonary resuscitation every 2 minutes. Method of measurement: A SP-20 handheld pulse oximeter made in Germany in 2019.;Arterial blood gases. Timepoint: 2 minutes immediately after starting CPR and 1 minute after achieving ROSC. Method of measurement: ABG device made in America model GEM 2000.	—

Measure

Time frame

End-tidal carbon dioxide. Timepoint: During cardiopulmonary resuscitation every 2 minutes. Method of measurement: A Sidestream portable capnography device from Comdek company, model MD-660P, made in Taiwan and manufactured in 2005.;Arterial oxygen saturation. Timepoint: During cardiopulmonary resuscitation every 2 minutes. Method of measurement: A SP-20 handheld pulse oximeter made in Germany in 2019.;Arterial blood gases. Timepoint: 2 minutes immediately after starting CPR and 1 minute after achieving ROSC. Method of measurement: ABG device made in America model GEM 2000.

—

Secondary

Measure	Time frame
Perfusion index. Timepoint: Every two minutes during CPR. Method of measurement: With pulseoximeter.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactNastaran Lotfi

Mashhad University of Medical Sciences

nastaran.lotfi1378@gmail.com+98 51 3843 0784

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026