Investigating the Effect of High-Flow Oxygen Administration on the Weaning Outcomes of Patients from Mechanical Ventilation After Coronary Artery Bypass Graft Surgery

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20240104060613N1

Enrollment

Registered

2024-02-02

Start date

2024-01-16

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Artery Disease. Atherosclerotic heart disease of native coronary artery

Interventions

Intervention 1: Intervention Group: In the intervention group, after extubation, high-flow oxygen therapy will be administered using a high-flow oxygen delivery device through a nasal cannula for up t

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Age =18 years old Mechanical ventilation for a minimum of 12 hours and a maximum of 48 hours No significant bleeding occurred post-surgery (defined as bleeding from the chest tube exceeding 200 ml every hour in the first three hours post-operation).

Exclusion criteria

Exclusion criteria: Severe pneumonia and acute respiratory failure during the study Persistent ventricular tachycardia requiring therapeutic intervention Unplanned extubation by the patient Need for tracheostomy placement

Design outcomes

Primary

Measure	Time frame
Reintubation rate. Timepoint: Forty-eight hours after weaning patients from the ventilator. Method of measurement: Extubation intolerance leading to respiratory failure and reintubation within 48 hours of weaning.;Arterial blood carbon dioxide pressure (PaCO2). Timepoint: Measurements will be recorded immediately before extubation, and then 6 and 12 hours post-extubation. Method of measurement: It will be measured through arterial blood gas analysis.;Arterial oxygen pressure (PaO2). Timepoint: Measurements will be recorded immediately before extubation, and then 6 and 12 hours post-extubation. Method of measurement: It will be measured through arterial blood gas analysis.;Arterial blood bicarbonate (HCO3). Timepoint: Measurements will be recorded immediately before extubation, and then 6 and 12 hours post-extubation. Method of measurement: It will be measured through arterial blood gas analysis.;Arterial oxygen saturation percentage (SPO2). Timepoint: Measurements will be recorded immediately before extubation, and then 6 and 12 hours post-extubation. Method of measurement: It is measured through pulse oximeter and arterial blood gas analysis.;PaO2/FiO2 ratio. Timepoint: Measurements will be recorded immediately before extubation, and then 6 and 12 hours post-extubation. Method of measurement: It is calculated by dividing the arterial blood oxygen pressure measured by arterial blood gas analysis by the percentage fractional inspired oxygen (PaO2/FiO2).;Heart Rate (HR). Timepoint: Measurements will be recorded immediately before extubation, and then 6 and 12 hours post-extubation. Method of measurement: Heart rate is measured via bedside monitoring.;Mean arterial pressure (MAP). Timepoint: Measurements will be recorded immediately before extubation, and then 6 and 12 hours post-extubation. Method of measurement: Mean arterial pressure (MAP) is measured via patient bedside monitoring.;Systolic blood pressure (SBP). Timepoint: Measurements will be recorded immediately	—

Measure

Time frame

Reintubation rate. Timepoint: Forty-eight hours after weaning patients from the ventilator. Method of measurement: Extubation intolerance leading to respiratory failure and reintubation within 48 hours of weaning.;Arterial blood carbon dioxide pressure (PaCO2). Timepoint: Measurements will be recorded immediately before extubation, and then 6 and 12 hours post-extubation. Method of measurement: It will be measured through arterial blood gas analysis.;Arterial oxygen pressure (PaO2). Timepoint: Measurements will be recorded immediately before extubation, and then 6 and 12 hours post-extubation. Method of measurement: It will be measured through arterial blood gas analysis.;Arterial blood bicarbonate (HCO3). Timepoint: Measurements will be recorded immediately before extubation, and then 6 and 12 hours post-extubation. Method of measurement: It will be measured through arterial blood gas analysis.;Arterial oxygen saturation percentage (SPO2). Timepoint: Measurements will be recorded immediately before extubation, and then 6 and 12 hours post-extubation. Method of measurement: It is measured through pulse oximeter and arterial blood gas analysis.;PaO2/FiO2 ratio. Timepoint: Measurements will be recorded immediately before extubation, and then 6 and 12 hours post-extubation. Method of measurement: It is calculated by dividing the arterial blood oxygen pressure measured by arterial blood gas analysis by the percentage fractional inspired oxygen (PaO2/FiO2).;Heart Rate (HR). Timepoint: Measurements will be recorded immediately before extubation, and then 6 and 12 hours post-extubation. Method of measurement: Heart rate is measured via bedside monitoring.;Mean arterial pressure (MAP). Timepoint: Measurements will be recorded immediately before extubation, and then 6 and 12 hours post-extubation. Method of measurement: Mean arterial pressure (MAP) is measured via patient bedside monitoring.;Systolic blood pressure (SBP). Timepoint: Measurements will be recorded immediately

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Secondary

Measure	Time frame
ICU long stay (ILS). Timepoint: The duration of stay in the intensive care unit (ICU) for open-heart surgery patients is calculated from the day of admission to the day of discharge. Method of measurement: The number of days admitted to the intensive care unit of patients after coronary artery bypass graft surgery is calculated and recorded from the day of admission to the open heart intensive care unit until discharge from this unit.;Hospital long stay (HLS). Timepoint: From the day of coronary artery bypass surgery until the day of discharge from the hospital. Method of measurement: The number of days after coronary artery bypass graft surgery will be calculated and recorded from the day of admission to the intensive care unit until the day of discharge from the hospital.;Mortality. Timepoint: The mortality rate of patients from the time of admission to discharge from the hospital will be recorded in two groups of intervention and control. Method of measurement: The mortality rate of patients will be recorded until they are discharged from the hospital.	—

Measure

Time frame

ICU long stay (ILS). Timepoint: The duration of stay in the intensive care unit (ICU) for open-heart surgery patients is calculated from the day of admission to the day of discharge. Method of measurement: The number of days admitted to the intensive care unit of patients after coronary artery bypass graft surgery is calculated and recorded from the day of admission to the open heart intensive care unit until discharge from this unit.;Hospital long stay (HLS). Timepoint: From the day of coronary artery bypass surgery until the day of discharge from the hospital. Method of measurement: The number of days after coronary artery bypass graft surgery will be calculated and recorded from the day of admission to the intensive care unit until the day of discharge from the hospital.;Mortality. Timepoint: The mortality rate of patients from the time of admission to discharge from the hospital will be recorded in two groups of intervention and control. Method of measurement: The mortality rate of patients will be recorded until they are discharged from the hospital.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactAbdolrab Dorazehi

Zahedan University of Medical Sciences

abdoldora1990@gmail.com+98 54 3722 6364

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026