Investigating the effect of fentanyl with the combination of morphine, ketamine and lidocaine in pain after open heart surgery

Comparison of fentanyl pump analgesia (PCA) with the combination of morphine, ketamine and lidocaine on pain after coronary artery bypass grafting (CABG)

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20231227060539N1

Enrollment

Registered

2024-01-28

Start date

2024-03-20

Completion date

Unknown

Last updated

2024-03-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heart failure. Combined systolic (congestive) and diastolic (congestive) heart failure

Interventions

Intervention 1: The first intervention group, the group receiving fentanyl(Caspian Pharmaceutical Company) (500 mcg in a diluted solution of 100 cc of distilled water at a rate of 4 cc per hour). Inte

Eligibility

Sex/Gender

All

Age

30 Years to 80 Years

Inclusion criteria

Inclusion criteria: Candidates for elective CABG surgery Patients 30-80 years old Anesthesia class II, III Not receiving painkillers within 6 hours before surgery surgeryConsent to participate in the study EF > 40% Patients without a history of renal, hepatic, gastrointestinal, or pulmonary failure No alcohol or drug addiction

Exclusion criteria

Exclusion criteria: Pump time more than 120 minutes Simultaneous valve and CABG CABGReoperation to control bleeding and progressive heart failure (requiring high dose postoperative inotropes or IABP) Emergency surgery

Design outcomes

Primary

Measure	Time frame
Measurement of pain score in patients undergoing cabg. Timepoint: Pain score in hours 1, 2, 6, 12 after cabg patients. Method of measurement: Numeric rating scale for pain.	—

Secondary

Measure	Time frame
The level of patient satisfaction. Timepoint: 1, 2, 6, 12 hours after surgery. Method of measurement: Visual analogue scale.;Average systolic blood pressure. Timepoint: 1,2,6,12 hours after surgery. Method of measurement: Blood pressure cuff.;Average diastolic blood pressure. Timepoint: 1,2,6,12 hours after surgery. Method of measurement: Blood pressure cuff.;Average mean arterial pressure. Timepoint: 1,2,6,12 hours after surgery. Method of measurement: Blood pressure cuff.;Average heart rate. Timepoint: 1,2,6,12 hours after surgery. Method of measurement: Chest lead monitoring.;Average pain of patients. Timepoint: 1,2,6,12 hours after surgery. Method of measurement: Numeric rating scale.	—

Measure

Time frame

The level of patient satisfaction. Timepoint: 1, 2, 6, 12 hours after surgery. Method of measurement: Visual analogue scale.;Average systolic blood pressure. Timepoint: 1,2,6,12 hours after surgery. Method of measurement: Blood pressure cuff.;Average diastolic blood pressure. Timepoint: 1,2,6,12 hours after surgery. Method of measurement: Blood pressure cuff.;Average mean arterial pressure. Timepoint: 1,2,6,12 hours after surgery. Method of measurement: Blood pressure cuff.;Average heart rate. Timepoint: 1,2,6,12 hours after surgery. Method of measurement: Chest lead monitoring.;Average pain of patients. Timepoint: 1,2,6,12 hours after surgery. Method of measurement: Numeric rating scale.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDoctor Saiid Kashani

Bandare-abbas University of Medical Sciences

sdkashani486@gmail.com+98 76 3334 7000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026