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Investigating and comparing the effect of three therapeutic methods of Naproxen, hydroxyzine and Syrup Noscough as therapeutic methods for preventing bone pain caused by granulocyte-colony stimulating factor(GCSF )in cancer patients

Investigating and comparing the effect of three therapeutic methods of Naproxen, hydroxyzine and Syrup Noscough as therapeutic methods for treatment of the bone pain caused by granulocyte-colony stimulating factor(GCSF) in cancer patients

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20231227060538N1
Enrollment
123
Registered
2024-03-04
Start date
2024-03-20
Completion date
Unknown
Last updated
2024-03-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bone Pain Due to PEG G-CSF. Non-follicular lymphoma

Interventions

Intervention 1: Intervention group:? The target intervention group (main): noscough syrup 15 cc daily orally, manufactured by Faran Chemi factory, and the duration of use is considered from the onset

Sponsors

Shahid Beheshti University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Inclusion criteria: patients with solid tumor or lymphoma Candidate for receiving Pegfilgrastim -after chemotherapy based on well known chemotherapy protocol

Exclusion criteria

Exclusion criteria: Bone metastasis in patients with progression free survival(PFS )greater than 2 Test-proven osteomalacia chronic kidney disease or end stage renal disease patients Patients with active rheumatic disease diabetes Uncontrolled thyroid disease Patients receiving chemotherapy drugs in which bone pain is one of the complications with a high incidence of 10% (TAXAN family, bisphosphonate.) Patients with pathological fracture or fracture due to any other reason Opioid addicts Contraindications for taking naproxen and methadone and other similar drugs Vitamin D level less than 20 Paget's disease Hyperparathyroid disease Patients who have bone pains in the questionnaire with a score above 6 since the beginning of the project liver disease Patients with a history of cardiac arrhythmia Patients who do not have the appropriate admission to fill out the pain questionnaire

Design outcomes

Primary

MeasureTime frame
Pain Score in Visual Analogue Scale(VAS) questionnaire. Timepoint: One day after the end of the first, second, third and fourth course of chemotherapy. Method of measurement: Visual Analogue Scale questionnaire.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFatemeh Talebian Taheri

Shahid Beheshti University of Medical Sciences

fatimatalebian@ymail.com+98 21 7343 0000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026