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Investigating the effect of dexamethasone injection in the first 24 hours in preventing kidney scaring in children with pyelonephritis

Investigating the effect of dexamethasone injection in the first 24 hours in preventing kidney scaring in children with pyelonephritis

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20231226060526N1
Enrollment
100
Registered
2024-02-13
Start date
2024-02-20
Completion date
Unknown
Last updated
2024-03-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute pyelonephritis. Vesicoureteral-reflux

Interventions

Sponsors

Sanandaj University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
1 Years to 12 Years

Inclusion criteria

Inclusion criteria: Children from 1 month to 12 years with first episode of fever T > 38°C having a urinary tract infection and a positive urine culture The presence of a positive urine culture, which according to the definition includes at least 100000 CFUs/mL from a clean sample obtained with a urine bag, or at least 10000 CFUs/mL from a sample obtained by catheterization, or the growth of any amount of bacteria from a sample obtained by suprapubic aspiration.

Exclusion criteria

Exclusion criteria: Endocrine disease Immunosuppressive therapy Known cancer or uropathy Those who had an abnormal DMSA before late assessment (at least 6 months follow-up) had a second UTI.

Design outcomes

Primary

MeasureTime frame
Primary outcome of presence of renal scar in Dimercaptosuccinic acid renal scan. Timepoint: 6-month follow-up. Method of measurement: Dimercaptosuccinic acid (DMSA) renal scan.

Secondary

MeasureTime frame
The presence of kidney scar in children groups A and B with higher Procalcitonin and the acceptability of steroid adjuvant in terms of the amount of treatment and side effects. Timepoint: 6-month follow-up. Method of measurement: Dimercaptosuccinic acid (DMSA) renal scan.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSeyyed Zia Hijazi

Sanandaj University of Medical Sciences

szhejazi1402@gmail.com+98 87 6664 6580

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026