The Effect of Diet with probiotic on Cardiovascular Function

The Effect of Sustainable Diet Combined with Time-Restricted Eating and Probiotic Supplementation on Cardiovascular Function among Patients with Chronic Heart Failure with reduced Ejection Fraction (HFrEF): A Randomized Clinical Trial Study

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20231225060520N1

Enrollment

Registered

2024-01-23

Start date

2025-04-04

Completion date

Unknown

Last updated

2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with Chronic Heart Failure with reduced Ejection Fraction (HFrEF). Heart failure, unspecified

Interventions

Intervention 1: First Intervention group: Dietary advices + Probiotic placebo (without Lactobacillus plantarum 299v, twice daily for 60 days). Intervention 2: Second Intervention group: ?Sustainable d

Eligibility

Sex/Gender

All

Age

30 Years to 75 Years

Inclusion criteria

Inclusion criteria: Clinical diagnosis of heart failure with echocardiogram showing systolic dysfunction with ejection fraction = 40% based on New York Heart Association (NYHA) class II-IIID heart failure symptoms with ischemic or non-ischemic etiology Under standard treatment with drugs Men and women with age range of 30-75 years Willingness to participate in the study and complete the informed consent form

Exclusion criteria

Exclusion criteria: Use of nutritional supplements (oral or injectable, such as vitamins D, C, E, calcium, magnesium, potassium, multivitamin- mineral, omega 3) and herbal products with antioxidant and anti-inflammatory properties, probiotic or synbiotic supplements or products containing them during the study Not consuming more than 20% of the capsules Unwillingness to continue cooperation in research

Design outcomes

Primary

Measure	Time frame
N Terminal pro Natriuretic Peptide type B (NT-proBNP). Timepoint: In the beginning of the study (before the start of the intervention) and 60 days after the intervention. Method of measurement: Kit for measuring N-terminal pro-natriuretic peptide type B in venous blood sample.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactPegah Rahbarinejad

Mashhad University of Medical Sciences

pegah.rahbarinejad@gmail.com+98 21 8827 1524

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026