Acute ocular chemical burn. Chemical burn of cornea and conjunctival sac
Conditions
Interventions
Intervention 1: Intervention group: Intralimbal injection of bone marrow-derived MSCs with a dose of 5 million in 0.5cc one time 2 weeks after presentation. Intervention 2: Control group: Conventiona
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Age between 18 to 65 years Chemical ocular burn At most 2 weeks after the time of occurrence of the chemical ocular burn Burn severity should be grade 5 or 6 according to Dua standard 2001 Patients should enter the study with informed consent and commit to follow-up for at least 3 months
Exclusion criteria
Exclusion criteria: Total blindness (NLP) in either of the eyes Perforated or near-perforated cornea (thinning more than two-thirds of the thickness of the cornea) Indications for other surgery due to complications History of corneal surgery or previous corneal diseases History of ophthalmologic surgery or radiotherapy on the eye Presence of infectious corneal ulcer or endophthalmitis Blepharal pathology including full thickness defect, entropion and ectropion IOP>25mmHg despite taking antiglaucoma drugs Existence of a dangerous underlying disease; Such as uncontrolled blood pressure (>150.95 mmHg), liver or kidney dysfunction Pregnant or lactating woman Neurological disorders
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Visual acuity. Timepoint: one month. Method of measurement: Clinical exam.;Conjunctivalization grade. Timepoint: One month. Method of measurement: Slit lamp examination. | — |
Primary
| Measure | Time frame |
|---|---|
| Size of corneal epithelial defect. Timepoint: one week. Method of measurement: Slit lamp examination / Fluorescein staining.;Conjunctival epithelial defect. Timepoint: one week. Method of measurement: Slit lamp examination / Fluorescein staining. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMehran Zarei Ghanavati
Tehran University of Medical Sciences
Outcome results
None listed