Fatty liver. Fatty (change of) liver, not elsewhere classified
Conditions
Interventions
Intervention 1: Intervention group: Patients in the supplement group will take every 12 hours, 2 tablespoons of oral emulsion, each spoon containing 500 mg of Pistacia atlantica Sub Kurdica gum for 2
Sponsors
Kermanshah University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Having fatty liver grade 1 and 2 based on diagnosis by ultrasound Age 18-60 years Body mass index in the range of 25-35 kg/m2
Exclusion criteria
Exclusion criteria: The presence of secondary causes of hepatic steatosis (such as hepatitis B and C virus, autoimmune hepatitis, hemochromatosis, celiac disease, pituitary hypofunction, hypothyroidism, Wilson's disease, abetalipoproteinemia or corticosteroid drugs) Suffering from diseases such as Autoimmune, digestive, liver diseases (fibrosis, cirrhosis, (HCC, kidney, thyroid and cardiovascular diseases), severe respiratory disease (asthma and chronic bronchitis) Pregnancy Breastfeeding Alcohol consumption, consumption of plant sterols, psyllium and oil Fish, consumption of any kind of vitamins and minerals, nutritional supplements The existence of allergy to all kinds of Pistachio plant species
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Oxidative stress indicators (MDA, TAC, TOS). Timepoint: Before and after study. Method of measurement: Calorimetric method.;Gene expression of antioxidant enzymes (NQO1, HMOX-1, GCLC). Timepoint: Before and after study. Method of measurement: Real- Time PCR.;Nrf-2 gene expression. Timepoint: Before and after study. Method of measurement: Real- Time PCR.;Serum levels of inflammatory and anti-inflammatory factors (IL-10, IL-6). Timepoint: Before and after study. Method of measurement: ELIZA method. | — |
Secondary
| Measure | Time frame |
|---|---|
| Fasting insulin. Timepoint: Before and after study. Method of measurement: Calorimetric method.;Fasting blood sugar. Timepoint: Before and after study. Method of measurement: Calorimetric method.;Insulin resistance index (HOMA-IR). Timepoint: Before and after study. Method of measurement: Formula.;Insulin sensitivity index (QUICKI). Timepoint: Before and after study. Method of measurement: Formula.;Function of pancreatic beta cells (HOMA-ß). Timepoint: Before and after study. Method of measurement: Formula.;Liver enzymes (AST, ALT). Timepoint: Before and after study. Method of measurement: Calorimetric method.;Lipid profile (TC, HDL-C, TG, LDL-c). Timepoint: Before and after study. Method of measurement: Enzymatic method.;The degree of hepatic steatosis. Timepoint: Before and after study. Method of measurement: sonography. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactRoghayeh Mostafaei
Kermanshah University of Medical Sciences
Outcome results
None listed