Investigating the effect of Helicobacter pylori treatment regimen on osteoarthritis

Investigating the effect of Helicobacter pylori treatment regimen on improving pain and arthritis symptoms in patients with osteoarthritis

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20231216060428N1

Enrollment

Registered

2024-01-24

Start date

2024-01-27

Completion date

Unknown

Last updated

2024-03-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoarthritis. Osteoarthritis of knee

Interventions

Intervention 1: IIntervention group: people suffering from osteoarthritis, whose presence of posituve Helicobacter pylori has been proven by endoscopy, fecal test or serology test. For this group, in

Eligibility

Sex/Gender

All

Age

50 Years to No maximum

Inclusion criteria

Inclusion criteria: Age over 50 years Osteoarthritis diagnosis according to the findings of the graphy, examination and Clinical diagnosis of a specialist doctor Presence of positiveHelicobacter pylori infection based on endoscopy, fecal antigen test or serum antibody Patient consent to enter the study

Exclusion criteria

Exclusion criteria: The presence of immunodeficiency disease, active cancer and other rheumatological diseases in the patient lack of consent to participate and the patient's request to withdraw from the research plan recent use of antibiotics

Design outcomes

Primary

Measure	Time frame
Severity of Pain. Timepoint: Measurement of pain severity before the intervention and 4 and 8 weeks after the intervention. Method of measurement: WOMAC questionnaire, ten-point visual assessment of pain intensity (VAS), 5-question European quality of life (EQ-5D-3L).;Joint stiffness. Timepoint: before the intervention and four and eight weeks after starting Helicobacter pylori treatment regimen. Method of measurement: WOMAC questionnaire.;Disease activity. Timepoint: before the intervention and four and eight weeks after starting Helicobacter pylori treatment regimen. Method of measurement: WOMAC questionnaire.;Quality of Life. Timepoint: before the intervention and Four and eight weeks after starting Helicobacter pylori treatment regimen. Method of measurement: Ten-point visual assessment of pain intensity (VAS), 5-question European quality of life (EQ-5D-3L).;Physical performance. Timepoint: Measurement of Physical performance before the intervention and 4 and 8 weeks after the intervention. Method of measurement: WOMAC questionnaire.	—

Measure

Time frame

Severity of Pain. Timepoint: Measurement of pain severity before the intervention and 4 and 8 weeks after the intervention. Method of measurement: WOMAC questionnaire, ten-point visual assessment of pain intensity (VAS), 5-question European quality of life (EQ-5D-3L).;Joint stiffness. Timepoint: before the intervention and four and eight weeks after starting Helicobacter pylori treatment regimen. Method of measurement: WOMAC questionnaire.;Disease activity. Timepoint: before the intervention and four and eight weeks after starting Helicobacter pylori treatment regimen. Method of measurement: WOMAC questionnaire.;Quality of Life. Timepoint: before the intervention and Four and eight weeks after starting Helicobacter pylori treatment regimen. Method of measurement: Ten-point visual assessment of pain intensity (VAS), 5-question European quality of life (EQ-5D-3L).;Physical performance. Timepoint: Measurement of Physical performance before the intervention and 4 and 8 weeks after the intervention. Method of measurement: WOMAC questionnaire.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactGhazaleh Heidari Soodejani

Shahre-kord University of Medical Sciences

ghazaleh.heidari.1992@gmail.com+98 38 3222 0016

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026